2020
Reliable prediction of survival in advanced-stage hepatocellular carcinoma treated with sorafenib: comparing 1D and 3D quantitative tumor response criteria on MRI
Doemel LA, Chapiro J, Laage Gaupp F, Savic LJ, Kucukkaya AS, Petukhova A, Tefera J, Zeevi T, Lin M, Schlachter T, Jaffe A, Strazzabosco M, Patel T, Stein SM. Reliable prediction of survival in advanced-stage hepatocellular carcinoma treated with sorafenib: comparing 1D and 3D quantitative tumor response criteria on MRI. European Radiology 2020, 31: 2737-2746. PMID: 33123796, PMCID: PMC8043967, DOI: 10.1007/s00330-020-07381-9.Peer-Reviewed Original ResearchConceptsTumor response criteriaOverall survivalAdvanced-stage HCCDisease progressionSorafenib therapyDisease controlResponse criteriaCox proportional hazards regression modelAdvanced-stage hepatocellular carcinomaProportional hazards regression modelsDCE-MRIInitiation of sorafenibTumor response analysisMultivariable Cox regressionIndependent risk factorMethodsThis retrospective analysisIndependent prognostic factorInitiation of treatmentKaplan-Meier analysisKaplan-Meier curvesHazards regression modelsLog-rank testStratification of patientsTotal tumor volumeArterial phase MRI
2016
Advanced-stage hepatocellular carcinoma with portal vein thrombosis: conventional versus drug-eluting beads transcatheter arterial chemoembolization
Gorodetski B, Chapiro J, Schernthaner R, Duran R, Lin M, Lee H, Lenis D, Stuart EA, Nonyane BA, Pekurovsky V, Tamrazi A, Gebauer B, Schlachter T, Pawlik TM, Geschwind JF. Advanced-stage hepatocellular carcinoma with portal vein thrombosis: conventional versus drug-eluting beads transcatheter arterial chemoembolization. European Radiology 2016, 27: 526-535. PMID: 27277261, PMCID: PMC5470590, DOI: 10.1007/s00330-016-4445-9.Peer-Reviewed Original ResearchConceptsMedian overall survivalPortal venous thrombosisAdvanced-stage hepatocellular carcinomaConventional TACEDEB-TACEHepatocellular carcinomaOverall survivalAdverse eventsBeads TACEDrug-eluting bead transcatheter arterial chemoembolizationConventional trans-arterial chemoembolizationPropensity scoreDrug-eluting beads TACECommon adverse eventsConclusionOur retrospective studyEqual safety profileChild-Pugh classMethodsThis retrospective analysisPortal vein thrombosisPost-embolization syndromeTranscatheter arterial chemoembolizationStage hepatocellular carcinomaTrans-arterial chemoembolizationSub-group analysisArterial chemoembolization
2014
Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
Chapiro J, Sur S, Savic LJ, Ganapathy-Kanniappan S, Reyes J, Duran R, Thiruganasambandam SC, Moats CR, Lin M, Luo W, Tran PT, Herman JM, Semenza GL, Ewald AJ, Vogelstein B, Geschwind JF. Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer. Clinical Cancer Research 2014, 20: 6406-6417. PMID: 25326230, PMCID: PMC4300523, DOI: 10.1158/1078-0432.ccr-14-1271.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaSuit-2 cell lineOrthotopic xenograft mouse modelBioluminescence imagingFavorable toxicity profileSublethal drug concentrationsAnti-invasive effectsXenograft mouse modelPDAC cell linesCell linesXenograft tumor modelHalf maximal inhibitory concentrationStrong anticancer effectsPancreatic cancerClinical trialsDuctal adenocarcinomaMouse modelToxicity profileIC50 profileTherapeutic efficacyMatrigel invasionVivo efficacyBLI signalMatrigel assaysMiaPaCa-2Reversal of Anchorage-Independent Multicellular Spheroid into a Monolayer Mimics a Metastatic Model
Kunjithapatham R, Karthikeyan S, Geschwind JF, Kieserman E, Lin M, Fu DX, Ganapathy-Kanniappan S. Reversal of Anchorage-Independent Multicellular Spheroid into a Monolayer Mimics a Metastatic Model. Scientific Reports 2014, 4: 6816. PMID: 25351825, PMCID: PMC4212233, DOI: 10.1038/srep06816.Peer-Reviewed Original ResearchConceptsMetastatic phenotypeAnchorage-independent growthMolecular regulationMulticellular spheroidsStem cell markersMolecular eventsCancer stem cell markersVitro modelModel of metastasisMetastatic processSpecific therapeutic targetsTherapeutic targetAntimetastatic agentPhenotypeMetastatic modelRegulationVivo dataExpressionChemoresistanceInvasivenessSpheroidsMajor impedimentInductionMimicsGrowthThree-dimensional Evaluation of Lipiodol Retention in HCC after Chemoembolization A Quantitative Comparison between CBCT and MDCT
Wang Z, Lin M, Lesage D, Chen R, Chapiro J, Gu T, Tacher V, Duran R, Geschwind JF. Three-dimensional Evaluation of Lipiodol Retention in HCC after Chemoembolization A Quantitative Comparison between CBCT and MDCT. Academic Radiology 2014, 21: 393-399. PMID: 24507426, PMCID: PMC3979929, DOI: 10.1016/j.acra.2013.11.006.Peer-Reviewed Original ResearchAgedAntineoplastic AgentsCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyEthiodized OilFemaleHemostaticsHumansImaging, Three-DimensionalLiver NeoplasmsMaleMetabolic Clearance RateMiddle AgedMultidetector Computed TomographyReproducibility of ResultsSensitivity and SpecificityTissue DistributionTreatment Outcome
2012
Quantitative and Volumetric European Association for the Study of the Liver and Response Evaluation Criteria in Solid Tumors Measurements: Feasibility of a Semiautomated Software Method to Assess Tumor Response after Transcatheter Arterial Chemoembolization
Lin M, Pellerin O, Bhagat N, Rao P, Loffroy R, Ardon R, Mory B, Reyes D, Geschwind J. Quantitative and Volumetric European Association for the Study of the Liver and Response Evaluation Criteria in Solid Tumors Measurements: Feasibility of a Semiautomated Software Method to Assess Tumor Response after Transcatheter Arterial Chemoembolization. Journal Of Vascular And Interventional Radiology 2012, 23: 1629-1637. PMID: 23177109, PMCID: PMC3579576, DOI: 10.1016/j.jvir.2012.08.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic AgentsCarcinoma, HepatocellularChemoembolization, TherapeuticFemaleHumansImaging, Three-DimensionalLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPattern Recognition, AutomatedReproducibility of ResultsSensitivity and SpecificitySoftwareSoftware ValidationTreatment OutcomeTumor BurdenConceptsTranscatheter arterial chemoembolizationArterial chemoembolizationHepatocellular carcinomaDrug-eluting bead transcatheter arterial chemoembolizationSingle-institution prospective studyResponse Evaluation CriteriaContrast-enhanced magnetic resonanceHepatic tumor volumeSolid tumor measurementsThree-dimensional volumetric assessmentMagnetic resonanceIntraarterial therapyProspective studyTumor responseClinical correlationTumor measurementsTumor volumeTumor enhancementInterventional radiologistsPatientsVolumetric assessmentChemoembolizationEuropean AssociationVolume assessmentVoxel basis