2019
Quantitative Imaging Biomarkers for 90Y Distribution on Bremsstrahlung SPECT After Resin-Based Radioembolization
Schobert I, Chapiro J, Nezami N, Hamm CA, Gebauer B, Lin M, Pollak J, Saperstein L, Schlachter T, Savic LJ. Quantitative Imaging Biomarkers for 90Y Distribution on Bremsstrahlung SPECT After Resin-Based Radioembolization. Journal Of Nuclear Medicine 2019, 60: 1066-1072. PMID: 30655331, PMCID: PMC6681698, DOI: 10.2967/jnumed.118.219691.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiographyBiomarkersCarcinoma, HepatocellularEmbolization, TherapeuticFeasibility StudiesFemaleHumansImaging, Three-DimensionalLiverLiver NeoplasmsMagnetic Resonance ImagingMaleMicrospheresMiddle AgedMultimodal ImagingPrognosisRegression AnalysisRetrospective StudiesTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedTreatment OutcomeYttrium RadioisotopesConceptsNon-HCC patientsTransarterial radioembolizationHepatocellular carcinomaBaseline imagingTumor responseTumor volumeChild-Pugh class B patientsBaseline imaging featuresClass B patientsNormal liver ratiosTotal tumor volumeSPECT/CTContrast-enhanced MRIQuantitative European AssociationMultiphasic contrast-enhanced MRIInstitutional review boardHigh TNRPreprocedural MRIChild-PughB patientsLiver criteriaTumor burdenClinical parametersHepatic malignanciesRetrospective study
2016
A Novel Inherently Radiopaque Bead for Transarterial Embolization to Treat Liver Cancer - A Pre-clinical Study
Duran R, Sharma K, Dreher MR, Ashrafi K, Mirpour S, Lin M, Schernthaner RE, Schlachter TR, Tacher V, Lewis AL, Willis S, Hartog M, Radaelli A, Negussie AH, Wood BJ, Geschwind JF. A Novel Inherently Radiopaque Bead for Transarterial Embolization to Treat Liver Cancer - A Pre-clinical Study. Theranostics 2016, 6: 28-39. PMID: 26722371, PMCID: PMC4679352, DOI: 10.7150/thno.13137.Peer-Reviewed Original ResearchConceptsEquilibrium water contentDurable suspensionLower equilibrium water contentPhysicomechanical propertiesBead locationSingle shotBead sizeSize distributionSimilar penetrationSimilar size distributionX-ray attenuationBead typesWater contentDeliverabilityBeadsLC beadsHigh densitySuspension timePenetrationCone-beam CTDensityRoMicroshperesSuspensionNon-target arteries
2015
Comparison of Existing Response Criteria in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Using a 3D Quantitative Approach.
Tacher V, Lin M, Duran R, Yarmohammadi H, Lee H, Chapiro J, Chao M, Wang Z, Frangakis C, Sohn JH, Maltenfort MG, Pawlik T, Geschwind JF. Comparison of Existing Response Criteria in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Using a 3D Quantitative Approach. Radiology 2015, 278: 275-84. PMID: 26131913, PMCID: PMC4695977, DOI: 10.1148/radiol.2015142951.Peer-Reviewed Original Research
2013
Can C-Arm Cone-Beam CT Detect a Micro-Embolic Effect After TheraSphere Radioembolization of Neuroendocrine and Carcinoid Liver Metastasis?
Pellerin O, Lin M, Bhagat N, Shao W, Geschwind J. Can C-Arm Cone-Beam CT Detect a Micro-Embolic Effect After TheraSphere Radioembolization of Neuroendocrine and Carcinoid Liver Metastasis? Cancer Biotherapy & Radiopharmaceuticals 2013, 28: 459-465. PMID: 23484809, PMCID: PMC3715773, DOI: 10.1089/cbr.2012.1390.Peer-Reviewed Original ResearchConceptsTumor enhancementHounsfield unitsArterial phaseCapillary levelCarcinoid liver metastasesYttrium-90 microspheresHigh-dose radiationEarly arterial phaseContrast medium injectionC-arm cone-beam CTTheraSphere radioembolizationLiver metastasesNeuroendocrine tumorsHepatic tumorsDelayed phasesRadioembolizationTumor densityMedium injectionTumor attenuationTumor vesselsTumorsTheraSphereEmbolic effectCone-beam CTSignificant decrease
2012
Phase II Study of Chemoembolization With Drug-Eluting Beads in Patients With Hepatic Neuroendocrine Metastases: High Incidence of Biliary Injury
Bhagat N, Reyes D, Lin M, Kamel I, Pawlik T, Frangakis C, Geschwind J. Phase II Study of Chemoembolization With Drug-Eluting Beads in Patients With Hepatic Neuroendocrine Metastases: High Incidence of Biliary Injury. CardioVascular And Interventional Radiology 2012, 36: 449-459. PMID: 22722717, PMCID: PMC3596485, DOI: 10.1007/s00270-012-0424-y.Peer-Reviewed Original ResearchConceptsTransarterial chemoembolizationTumor sizeNeuroendocrine tumorsHigh incidenceNational Cancer Institute Common Terminology CriteriaEastern Cooperative Oncology Group statusHepatic neuroendocrine metastasesUnderwent percutaneous drainageCommon Terminology CriteriaObjective response ratePhase II studyPhase II trialMultiple small lesionsMethodsInstitutional review board approvalDrug-eluting beadsReview board approvalAlanine amino transferaseTerminology CriteriaAbdominal painBiliary injuryII trialDEB-TACEII studyEASL criteriaPercutaneous drainage
2010
Evaluating tumors in transcatheter arterial chemoembolization (TACE) using dual-phase cone-beam CT
Lin M, Loffroy R, Noordhoek N, Taguchi K, Radaelli A, Blijd J, Balguid A, Geschwind J. Evaluating tumors in transcatheter arterial chemoembolization (TACE) using dual-phase cone-beam CT. Minimally Invasive Therapy & Allied Technologies 2010, 20: 276-281. PMID: 21082901, PMCID: PMC4337876, DOI: 10.3109/13645706.2010.536243.Peer-Reviewed Original ResearchConceptsTranscatheter arterial chemoembolizationTumor-feeding vesselsParenchymal stainingTACE treatmentArterial chemoembolizationContrast injectionDual-phase cone-beam CTTumor feeding vesselsDrug-eluting beadsContrast-enhanced scansDegree of embolizationFeeding vesselsMR/CTSingle injectionCatheter positionInitial experienceCBCT scansCone-beam CTEmbolization effectConventional CTCTChemoembolizationC-armInjectionCBCT system