2022
DuDoSS: Deep‐learning‐based dual‐domain sinogram synthesis from sparsely sampled projections of cardiac SPECT
Chen X, Zhou B, Xie H, Miao T, Liu H, Holler W, Lin M, Miller EJ, Carson RE, Sinusas AJ, Liu C. DuDoSS: Deep‐learning‐based dual‐domain sinogram synthesis from sparsely sampled projections of cardiac SPECT. Medical Physics 2022, 50: 89-103. PMID: 36048541, PMCID: PMC9868054, DOI: 10.1002/mp.15958.Peer-Reviewed Original ResearchConceptsLow reconstruction accuracySynthetic projectionsAbsolute percent errorImage predictionSPECT image reconstructionImage domainSinogram synthesisGround truthReconstruction accuracyImage reconstructionSinogram domainProjection angleData acquisitionMean square errorFast data acquisitionImagesReconstruction artifactsSPECT imagesSquare errorImpact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model
Berz AM, Santana JG, Iseke S, Gross M, Pekurovsky V, Laage Gaupp F, Savic LJ, Borde T, Gottwald LA, Boustani AM, Gebauer B, Lin M, Zhang X, Schlachter T, Madoff DC, Chapiro J. Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model. Journal Of Vascular And Interventional Radiology 2022, 33: 764-774.e4. PMID: 35346859, PMCID: PMC9344951, DOI: 10.1016/j.jvir.2022.03.026.Peer-Reviewed Original ResearchConceptsTranscatheter arterial chemoembolizationCytotoxic T-lymphocyte-associated protein 4Rabbit liver tumor modelConventional TACEImmune checkpoint marker expressionLiver tumor modelVX2 rabbit liver tumor modelArterial chemoembolizationBicarbonate infusionImmune responseDifferentiation 3T-lymphocyte-associated protein 4Conventional transcatheter arterial chemoembolizationTumor modelCell death protein 1Marker expressionIntratumoral T cellsImmune checkpoint markersT cell infiltrationDeath protein 1Antigen-presenting cellsImmune cell recruitmentNew Zealand white rabbitsZealand white rabbitsAPC infiltration
2021
Comparison of metabolic and immunologic responses to transarterial chemoembolization with different chemoembolic regimens in a rabbit VX2 liver tumor model
Doemel LA, Santana JG, Savic LJ, Gaupp FML, Borde T, Petukhova-Greenstein A, Kucukkaya AS, Schobert IT, Hamm CA, Gebauer B, Walsh JJ, Rexha I, Hyder F, Lin M, Madoff DC, Schlachter T, Chapiro J, Coman D. Comparison of metabolic and immunologic responses to transarterial chemoembolization with different chemoembolic regimens in a rabbit VX2 liver tumor model. European Radiology 2021, 32: 2437-2447. PMID: 34718844, PMCID: PMC9359419, DOI: 10.1007/s00330-021-08337-3.Peer-Reviewed Original ResearchConceptsDrug-eluting embolicsImmune cell infiltrationAntigen-presenting cellsBicarbonate infusionConventional TACEDEE-TACETransarterial chemotherapyCell infiltrationImmune cellsPeritumoral infiltrationT lymphocytesIntratumoral immune cell infiltrationTumor modelRabbit VX2 liver tumor modelImmunological tumor microenvironmentVX2 liver tumor modelIntra-arterial therapyIntra-arterial treatmentRabbit VX2 tumor modelLiver tumor modelTumor-bearing rabbitsVX2 tumor modelMann-Whitney U testIntratumoral presenceTransarterial chemoembolization
2020
Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment
Savic LJ, Schobert I, Peters D, Walsh JJ, Laage-Gaupp F, Hamm CA, Tritz N, Doemel LA, Lin M, Sinusas A, Schlachter T, Duncan JS, Hyder F, Coman D, Chapiro J. Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment. Clinical Cancer Research 2020, 26: 428-438. PMID: 31582517, PMCID: PMC7244230, DOI: 10.1158/1078-0432.ccr-19-1702.Peer-Reviewed Original ResearchConceptsMR spectroscopic imagingLocoregional therapyLiver cancer microenvironmentConventional transarterial chemoembolizationNew Zealand white rabbitsTumor pHMost liver tumorsZealand white rabbitsMolecular imaging paradigmsPositive therapeutic outcomesTumor residualsTransarterial chemoembolizationTumor devascularizationHistopathologic markersViable tumorSurrogate biomarkerLiver tumorsLiver cancerTumor enhancementLiver parenchymaMetabolic markersMultiparametric MRITherapeutic outcomesHIF-1αVX2 tumors
2016
A Novel Inherently Radiopaque Bead for Transarterial Embolization to Treat Liver Cancer - A Pre-clinical Study
Duran R, Sharma K, Dreher MR, Ashrafi K, Mirpour S, Lin M, Schernthaner RE, Schlachter TR, Tacher V, Lewis AL, Willis S, Hartog M, Radaelli A, Negussie AH, Wood BJ, Geschwind JF. A Novel Inherently Radiopaque Bead for Transarterial Embolization to Treat Liver Cancer - A Pre-clinical Study. Theranostics 2016, 6: 28-39. PMID: 26722371, PMCID: PMC4679352, DOI: 10.7150/thno.13137.Peer-Reviewed Original ResearchConceptsEquilibrium water contentDurable suspensionLower equilibrium water contentPhysicomechanical propertiesBead locationSingle shotBead sizeSize distributionSimilar penetrationSimilar size distributionX-ray attenuationBead typesWater contentDeliverabilityBeadsLC beadsHigh densitySuspension timePenetrationCone-beam CTDensityRoMicroshperesSuspensionNon-target arteries
2014
Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
Chapiro J, Sur S, Savic LJ, Ganapathy-Kanniappan S, Reyes J, Duran R, Thiruganasambandam SC, Moats CR, Lin M, Luo W, Tran PT, Herman JM, Semenza GL, Ewald AJ, Vogelstein B, Geschwind JF. Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer. Clinical Cancer Research 2014, 20: 6406-6417. PMID: 25326230, PMCID: PMC4300523, DOI: 10.1158/1078-0432.ccr-14-1271.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaSuit-2 cell lineOrthotopic xenograft mouse modelBioluminescence imagingFavorable toxicity profileSublethal drug concentrationsAnti-invasive effectsXenograft mouse modelPDAC cell linesCell linesXenograft tumor modelHalf maximal inhibitory concentrationStrong anticancer effectsPancreatic cancerClinical trialsDuctal adenocarcinomaMouse modelToxicity profileIC50 profileTherapeutic efficacyMatrigel invasionVivo efficacyBLI signalMatrigel assaysMiaPaCa-2Reversal of Anchorage-Independent Multicellular Spheroid into a Monolayer Mimics a Metastatic Model
Kunjithapatham R, Karthikeyan S, Geschwind JF, Kieserman E, Lin M, Fu DX, Ganapathy-Kanniappan S. Reversal of Anchorage-Independent Multicellular Spheroid into a Monolayer Mimics a Metastatic Model. Scientific Reports 2014, 4: 6816. PMID: 25351825, PMCID: PMC4212233, DOI: 10.1038/srep06816.Peer-Reviewed Original ResearchConceptsMetastatic phenotypeAnchorage-independent growthMolecular regulationMulticellular spheroidsStem cell markersMolecular eventsCancer stem cell markersVitro modelModel of metastasisMetastatic processSpecific therapeutic targetsTherapeutic targetAntimetastatic agentPhenotypeMetastatic modelRegulationVivo dataExpressionChemoresistanceInvasivenessSpheroidsMajor impedimentInductionMimicsGrowthThe Effect of Bilateral Superior Laryngeal Nerve Lesion on Swallowing: A Novel Method to Quantitate Aspirated Volume and Pharyngeal Threshold in Videofluoroscopy
Ding P, Fung G, Lin M, Holman S, German R. The Effect of Bilateral Superior Laryngeal Nerve Lesion on Swallowing: A Novel Method to Quantitate Aspirated Volume and Pharyngeal Threshold in Videofluoroscopy. Dysphagia 2014, 30: 47-56. PMID: 25270532, PMCID: PMC4351730, DOI: 10.1007/s00455-014-9572-3.Peer-Reviewed Original Research
2013
Image quality improvements in C-Arm CT (CACT) for liver oncology applications: Preliminary study in rabbits
Tacher V, Bhagat N, Rao P, Lin M, SchÄfer D, Noordhoek N, Eshuis P, Radaelli A, Liapi E, Grass M, Geschwind J. Image quality improvements in C-Arm CT (CACT) for liver oncology applications: Preliminary study in rabbits. Minimally Invasive Therapy & Allied Technologies 2013, 22: 297-303. PMID: 23837536, PMCID: PMC3859124, DOI: 10.3109/13645706.2013.788028.Peer-Reviewed Original ResearchConceptsC-arm CTAdult male New Zealand white rabbitsMale New Zealand white rabbitsIntra-arterial therapyNon-target embolizationNew Zealand white rabbitsZealand white rabbitsFuture animal studiesLiver tumorsControl rabbitsNew imaging modalityOncology therapyAnimal studiesWhite rabbitsImaging protocolImaging modalitiesRabbitsSelective deliveryTherapyLesion detectionCTClinical environmentStudy improvementRespiratory motionPreliminary study
2012
Intraprocedural C-Arm Dual-Phase Cone-Beam CT: Can It Be Used to Predict Short-term Response to TACE with Drug-eluting Beads in Patients with Hepatocellular Carcinoma?
Loffroy R, Lin M, Yenokyan G, Rao PP, Bhagat N, Noordhoek N, Radaelli A, Blijd J, Liapi E, Geschwind JF. Intraprocedural C-Arm Dual-Phase Cone-Beam CT: Can It Be Used to Predict Short-term Response to TACE with Drug-eluting Beads in Patients with Hepatocellular Carcinoma? Radiology 2012, 266: 636-648. PMID: 23143027, PMCID: PMC3558876, DOI: 10.1148/radiol.12112316.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArea Under CurveCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyDoxorubicinFemaleHumansLeast-Squares AnalysisLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsProspective StudiesRadiation DosageROC CurveSwineTreatment OutcomeConceptsDual-phase cone-beam CTTranscatheter arterial chemoembolizationPartial tumor responseDrug-eluting beadsTumor responseTumor enhancementCone-beam CT scansHepatocellular carcinomaLogistic regression modelsCone-beam CTVenous phaseCT scanMR findingsMultivariate logistic regression modelMR imagingHCC tumor responseRadiation doseDoxorubicin-eluting beadsMagnetic resonance imagingInstitutional review boardArterial chemoembolizationLiver (EASL) guidelinesRegression modelsProspective studyHCC lesionsComparison of Semi-automatic Volumetric VX2 Hepatic Tumor Segmentation from Cone Beam CT and Multi-detector CT with Histology in Rabbit Models
Pellerin O, Lin M, Bhagat N, Ardon R, Mory B, Geschwind J. Comparison of Semi-automatic Volumetric VX2 Hepatic Tumor Segmentation from Cone Beam CT and Multi-detector CT with Histology in Rabbit Models. Academic Radiology 2012, 20: 115-121. PMID: 22947274, PMCID: PMC3575098, DOI: 10.1016/j.acra.2012.07.011.Peer-Reviewed Original ResearchBehavior of Tip-Steerable Needles in Ex Vivo and In Vivo Tissue
Majewicz A, Marra S, van Vledder M, Lin M, Choti M, Song D, Okamura A. Behavior of Tip-Steerable Needles in Ex Vivo and In Vivo Tissue. IEEE Transactions On Biomedical Engineering 2012, 59: 2705-2715. PMID: 22711767, PMCID: PMC3448818, DOI: 10.1109/tbme.2012.2204749.Peer-Reviewed Original ResearchApplications of Imaging Technology in Radiation Research
Lin M, Jackson E. Applications of Imaging Technology in Radiation Research. Radiation Research 2012, 177: 387-397. PMID: 22401349, PMCID: PMC3355534, DOI: 10.1667/rr2696.1.Peer-Reviewed Original ResearchMeSH KeywordsAngiography, Digital SubtractionAnimalsArtifactsContrast MediaDiagnostic ImagingEmbolization, TherapeuticHumansLiver NeoplasmsMagnetic Resonance ImagingMathematicsModels, BiologicalMotionPerfusion ImagingRadiobiologyRadiography, InterventionalStrokeTomography, Spiral ComputedTomography, X-Ray Computed
2011
Phenylephrine-modulated cardiopulmonary blood flow measured with use of X-ray digital subtraction angiography
Lin M, Qi Y, Chen A, Badea C, Johnson G. Phenylephrine-modulated cardiopulmonary blood flow measured with use of X-ray digital subtraction angiography. Journal Of Pharmacological And Toxicological Methods 2011, 64: 180-186. PMID: 21846505, PMCID: PMC3200449, DOI: 10.1016/j.vascn.2011.08.001.Peer-Reviewed Original Research
2010
Evaluating tumors in transcatheter arterial chemoembolization (TACE) using dual-phase cone-beam CT
Lin M, Loffroy R, Noordhoek N, Taguchi K, Radaelli A, Blijd J, Balguid A, Geschwind J. Evaluating tumors in transcatheter arterial chemoembolization (TACE) using dual-phase cone-beam CT. Minimally Invasive Therapy & Allied Technologies 2010, 20: 276-281. PMID: 21082901, PMCID: PMC4337876, DOI: 10.3109/13645706.2010.536243.Peer-Reviewed Original ResearchConceptsTranscatheter arterial chemoembolizationTumor-feeding vesselsParenchymal stainingTACE treatmentArterial chemoembolizationContrast injectionDual-phase cone-beam CTTumor feeding vesselsDrug-eluting beadsContrast-enhanced scansDegree of embolizationFeeding vesselsMR/CTSingle injectionCatheter positionInitial experienceCBCT scansCone-beam CTEmbolization effectConventional CTCTChemoembolizationC-armInjectionCBCT system
2009
Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography
Lin M, Marshall C, Qi Y, Johnston S, Badea C, Piantadosi C, Johnson G. Quantitative blood flow measurements in the small animal cardiopulmonary system using digital subtraction angiography. Medical Physics 2009, 36: 5347-5358. PMID: 19994543, PMCID: PMC2780468, DOI: 10.1118/1.3231823.Peer-Reviewed Original Research