2018
Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma.
Abajian A, Murali N, Savic LJ, Laage-Gaupp FM, Nezami N, Duncan JS, Schlachter T, Lin M, Geschwind JF, Chapiro J. Predicting Treatment Response to Image-Guided Therapies Using Machine Learning: An Example for Trans-Arterial Treatment of Hepatocellular Carcinoma. Journal Of Visualized Experiments 2018 PMID: 30371657, PMCID: PMC6235502, DOI: 10.3791/58382.Peer-Reviewed Original ResearchConceptsIntra-arterial therapyN patientsHepatocellular carcinomaTrans-arterial therapiesIntra-arterial treatmentCohort of patientsStandard of careLikelihood of responseClinical research questionsSurgical resectionNew patientsTreatment responseUnivariate associationsPatientsTraining patientsInterventional radiologyTherapyCarcinomaTreatmentImage-guided therapyOutcomesFinal modelImaging dataResectionResponse
2017
The impact of antiangiogenic therapy combined with Transarterial Chemoembolization on enhancement based quantitative tumor response assessment in patients with hepatocellular carcinoma
Smolka S, Chapiro J, Manzano W, Treilhard J, Reiner E, Deng Y, Zhao Y, Hamm B, Duncan JS, Gebauer B, Lin M, Geschwind JF. The impact of antiangiogenic therapy combined with Transarterial Chemoembolization on enhancement based quantitative tumor response assessment in patients with hepatocellular carcinoma. Clinical Imaging 2017, 46: 1-7. PMID: 28668723, PMCID: PMC5720941, DOI: 10.1016/j.clinimag.2017.05.007.Peer-Reviewed Original ResearchConceptsEarly response assessmentTransarterial chemoembolizationImaging-based criteriaResponse assessmentHepatocellular carcinomaTumor response assessmentAnti-angiogenic therapyQuantitative European AssociationTherapy armOverall survivalLiver criteriaAntiangiogenic therapyTreatment groupsPatientsSimilar associationEuropean AssociationBevacizumabChemoembolizationCarcinomaTherapyAssociationAssessmentFollowCriteriaBaseline
2015
Evaluating Radiological Changes in Vestibular Schwannoma Patients Treated With Hypofractionated Stereotactic Radiation Therapy: A Potential Role for a Novel 3-D Quantitative Volumetric Assessment Tool
Marciscano A, Schneider T, Jusué-Torres I, Garg R, Rashid A, Chapiro J, Lin M, Geschwind J, Yousem D, Rigamonti D, Kleinberg L. Evaluating Radiological Changes in Vestibular Schwannoma Patients Treated With Hypofractionated Stereotactic Radiation Therapy: A Potential Role for a Novel 3-D Quantitative Volumetric Assessment Tool. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e114-e115. DOI: 10.1016/j.ijrobp.2015.07.839.Peer-Reviewed Original Research4:33 PM, Abstract No. 54 FEATURED ABSTRACT, Hong Kong liver cancer staging outperforms Barcelona clinic liver cancer staging as a prognostic classification system in patients treated with intra-arterial therapy: a North American study
Sohn J, Duran R, Lee H, Sahu S, Schernthaner R, Zhao L, Lin M, Fleckenstein F, Zhao Y, Geschwind J. 4:33 PM, Abstract No. 54 FEATURED ABSTRACT, Hong Kong liver cancer staging outperforms Barcelona clinic liver cancer staging as a prognostic classification system in patients treated with intra-arterial therapy: a North American study. Journal Of Vascular And Interventional Radiology 2015, 26: s30. DOI: 10.1016/j.jvir.2014.12.086.Peer-Reviewed Original Research
2014
Assessing tumor response after loco-regional liver cancer therapies: the role of 3D MRI
Chapiro J, Lin M, Duran R, Schernthaner RE, Geschwind JF. Assessing tumor response after loco-regional liver cancer therapies: the role of 3D MRI. Expert Review Of Anticancer Therapy 2014, 15: 199-205. PMID: 25371052, PMCID: PMC4304995, DOI: 10.1586/14737140.2015.978861.Peer-Reviewed Original ResearchConceptsTumor responseResponse Evaluation CriteriaTumor response criteriaMajor clinical interestLiver cancer therapyLiver cancer lesionsClinical evidenceIntraarterial therapyCancer lesionsSolid tumorsResponse criteriaAnatomic methodsClinical interestImaging modalitiesCancer therapyTumor analysisTherapyMRILesionsTumors1:39 PM Abstract No. 241 Quantitative 3D volumetric assessment of tumor response after intra-arterial therapy of colorectal cancer metastases to the liver – a new surrogate marker for survival
Chapiro J, Duran R, Lin M, Charu V, Wang Z, Tacher V, Lesage D, Geschwind J. 1:39 PM Abstract No. 241 Quantitative 3D volumetric assessment of tumor response after intra-arterial therapy of colorectal cancer metastases to the liver – a new surrogate marker for survival. Journal Of Vascular And Interventional Radiology 2014, 25: s113. DOI: 10.1016/j.jvir.2013.12.311.Peer-Reviewed Original Research
2013
Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
Tacher V, Lin M, Bhagat N, Jaoudeh N, Radaelli A, Noordhoek N, Carelsen B, Wood B, Geschwind J. Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization. Journal Of Visualized Experiments 2013, 50795. PMID: 24326874, PMCID: PMC3910428, DOI: 10.3791/50795.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaDP-CBCTDual phase CBCTDrug-eluting beadsCone-Beam Computed TomographyRole of CBCTMagnetic resonance imagingDEB-TACETreatment successInvasive therapyLiver tumorsComputed tomographyHCC treatmentInterventional radiologyResonance imagingAngiography suiteDiagnostic imagingSelective therapyCone beamDiagnostic accuracyCBCT techniqueInterventional suiteCarcinomaCBCTTherapyImage quality improvements in C-Arm CT (CACT) for liver oncology applications: Preliminary study in rabbits
Tacher V, Bhagat N, Rao P, Lin M, SchÄfer D, Noordhoek N, Eshuis P, Radaelli A, Liapi E, Grass M, Geschwind J. Image quality improvements in C-Arm CT (CACT) for liver oncology applications: Preliminary study in rabbits. Minimally Invasive Therapy & Allied Technologies 2013, 22: 297-303. PMID: 23837536, PMCID: PMC3859124, DOI: 10.3109/13645706.2013.788028.Peer-Reviewed Original ResearchConceptsC-arm CTAdult male New Zealand white rabbitsMale New Zealand white rabbitsIntra-arterial therapyNon-target embolizationNew Zealand white rabbitsZealand white rabbitsFuture animal studiesLiver tumorsControl rabbitsNew imaging modalityOncology therapyAnimal studiesWhite rabbitsImaging protocolImaging modalitiesRabbitsSelective deliveryTherapyLesion detectionCTClinical environmentStudy improvementRespiratory motionPreliminary study