2020
Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment
Savic LJ, Schobert I, Peters D, Walsh JJ, Laage-Gaupp F, Hamm CA, Tritz N, Doemel LA, Lin M, Sinusas A, Schlachter T, Duncan JS, Hyder F, Coman D, Chapiro J. Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment. Clinical Cancer Research 2020, 26: 428-438. PMID: 31582517, PMCID: PMC7244230, DOI: 10.1158/1078-0432.ccr-19-1702.Peer-Reviewed Original ResearchConceptsMR spectroscopic imagingLocoregional therapyLiver cancer microenvironmentConventional transarterial chemoembolizationNew Zealand white rabbitsTumor pHMost liver tumorsZealand white rabbitsMolecular imaging paradigmsPositive therapeutic outcomesTumor residualsTransarterial chemoembolizationTumor devascularizationHistopathologic markersViable tumorSurrogate biomarkerLiver tumorsLiver cancerTumor enhancementLiver parenchymaMetabolic markersMultiparametric MRITherapeutic outcomesHIF-1αVX2 tumors
2013
Quantitative Assessment of Lipiodol Deposition after Chemoembolization: Comparison between Cone-Beam CT and Multidetector CT
Chen R, Geschwind J, Wang Z, Tacher V, Lin M. Quantitative Assessment of Lipiodol Deposition after Chemoembolization: Comparison between Cone-Beam CT and Multidetector CT. Journal Of Vascular And Interventional Radiology 2013, 24: 1837-1844. PMID: 24094672, PMCID: PMC3840104, DOI: 10.1016/j.jvir.2013.08.017.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyContrast MediaEthiodized OilFemaleHumansImaging, Three-DimensionalLinear ModelsLiver NeoplasmsMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesTumor BurdenWorkflowConceptsTransarterial chemoembolizationLipiodol depositionHepatocellular carcinomaMultidetector CTConventional transarterial chemoembolizationVolume of tumorMargin of tumorUnenhanced multidetector CTUnenhanced multidetectorLipiodol retentionChemoembolizationLiver parenchymaTumorsEntire tumorLiver contrastCone beamCone-beam CTCTImaging modalitiesCBCTPatientsLipiodolWhole tumorVolumetric measurementsTomography