2022
Three-Dimensional Quantitative Tumor Response and Survival Analysis of Hepatocellular Carcinoma Patients Who Failed Initial Transarterial Chemoembolization: Repeat or Switch Treatment?
Zhao Y, Haroun R, Sahu S, Schernthaner R, Smolka S, Lin M, Hong K, Georgiades C, Duran R. Three-Dimensional Quantitative Tumor Response and Survival Analysis of Hepatocellular Carcinoma Patients Who Failed Initial Transarterial Chemoembolization: Repeat or Switch Treatment? Cancers 2022, 14: 3615. PMID: 35892874, PMCID: PMC9329887, DOI: 10.3390/cancers14153615.Peer-Reviewed Original ResearchOverall survivalSecond TACEHepatocellular carcinoma patientsFirst TACECarcinoma patientsTumor responseInitial transarterial chemoembolizationMedian overall survivalTransarterial chemoembolization sessionsKaplan-Meier methodLonger overall survivalLog-rank testChemoembolization sessionsConsecutive patientsTransarterial chemoembolizationSurvival outcomesHCC patientsTreatment responseTumor enhancementPatientsSurvival analysisTACEEuropean AssociationRespondersSignificant differences
2021
Longitudinal Analysis of the Effect of Repeated Transarterial Chemoembolization for Liver Cancer on Portal Venous Pressure
Frangakis C, Sohn JH, Bas A, Chapiro J, Schernthaner RE, Lin M, Hamilton JP, Pawlik TM, Hong K, Duran R. Longitudinal Analysis of the Effect of Repeated Transarterial Chemoembolization for Liver Cancer on Portal Venous Pressure. Frontiers In Oncology 2021, 11: 639235. PMID: 34804911, PMCID: PMC8602787, DOI: 10.3389/fonc.2021.639235.Peer-Reviewed Original ResearchPortal venous pressureChild-PughTransarterial chemoembolizationPlatelet countTumor burdenVenous pressureSpleen volumeHCC patientsEastern Cooperative Oncology Group performance statusEnd-stage liver disease (MELD) scorePortal hypertension-related complicationsNon-invasive surrogate markerBaseline spleen volumeBaseline tumor burdenRepeated Transarterial ChemoembolizationHigh tumor burdenHypertension-related complicationsLiver Disease scoreOutcomes of interestInstitutional review boardPost TACEPortal hypertensionMetastatic patientsPerformance statusBlood work
2016
3D Quantitative tumour burden analysis in patients with hepatocellular carcinoma before TACE: comparing single-lesion vs. multi-lesion imaging biomarkers as predictors of patient survival
Fleckenstein FN, Schernthaner RE, Duran R, Sohn JH, Sahu S, Zhao Y, Hamm B, Gebauer B, Lin M, Geschwind JF, Chapiro J. 3D Quantitative tumour burden analysis in patients with hepatocellular carcinoma before TACE: comparing single-lesion vs. multi-lesion imaging biomarkers as predictors of patient survival. European Radiology 2016, 26: 3243-3252. PMID: 26762942, PMCID: PMC4942412, DOI: 10.1007/s00330-015-4168-3.Peer-Reviewed Original ResearchConceptsHazard ratioOverall survivalTransarterial chemoembolizationBaseline MRIHepatocellular carcinomaTumor burdenDominant lesionTumor assessmentTumor volumeMultivariate cox proportional hazard ratiosCox proportional hazard ratiosCurrent radiological methodMethodsThis retrospective analysisProportional hazard ratiosBCLC staging systemKaplan-Meier plotsTumor diameterPatient survivalStaging systemHCC patientsMultiple lesionsLiver volumeRetrospective analysisLesion assessmentPatients
2015
Radiologic-pathologic analysis of quantitative 3D tumour enhancement on contrast-enhanced MR imaging: a study of ROI placement
Chockalingam A, Duran R, Sohn JH, Schernthaner R, Chapiro J, Lee H, Sahu S, Nguyen S, Geschwind JF, Lin M. Radiologic-pathologic analysis of quantitative 3D tumour enhancement on contrast-enhanced MR imaging: a study of ROI placement. European Radiology 2015, 26: 103-113. PMID: 25994198, PMCID: PMC4654989, DOI: 10.1007/s00330-015-3812-2.Peer-Reviewed Original ResearchConceptsTranscatheter arterial chemoembolizationHCC patientsIpsilateral placementTumor enhancementHepatocellular carcinoma patientsROI placementContrast-enhanced MR imagingRadiologic-pathologic analysisArterial chemoembolizationCarcinoma patientsPathological correlationIntra-class correlationPatientsMR imagingClinical methodsMedian differencePathologyInterest placementHistopathology8:00 AM, Abstract No. 260 Volumetric contrast patterns on intraprocedural cone-beam CT predicts tumor response: preliminary results in a prospective trial of HCC patients treated with DEBDOX-M1 bead TACE
Sahu S, Duran R, Schernthaner R, Sohn J, Reyes D, Lin M, Geschwind J. 8:00 AM, Abstract No. 260 Volumetric contrast patterns on intraprocedural cone-beam CT predicts tumor response: preliminary results in a prospective trial of HCC patients treated with DEBDOX-M1 bead TACE. Journal Of Vascular And Interventional Radiology 2015, 26: s119. DOI: 10.1016/j.jvir.2014.12.323.Peer-Reviewed Original Research
2014
9:03 AM; Abstract No. 87 Radio-pathological correlation of 3D-quantitative contrast-enhanced and functional MRI in HCC patients after TACE - do we see what we treat?
Chapiro J, Wood L, Cornish T, Lesage D, Charu V, Duran R, Tacher V, Wang Z, Lin M, Geschwind J. 9:03 AM; Abstract No. 87 Radio-pathological correlation of 3D-quantitative contrast-enhanced and functional MRI in HCC patients after TACE - do we see what we treat? Journal Of Vascular And Interventional Radiology 2014, 25: s46. DOI: 10.1016/j.jvir.2013.12.110.Peer-Reviewed Original Research