2013
Determination of the In Vivo Selectivity of a New κ-Opioid Receptor Antagonist PET Tracer 11C-LY2795050 in the Rhesus Monkey
Kim SJ, Zheng MQ, Nabulsi N, Labaree D, Ropchan J, Najafzadeh S, Carson RE, Huang Y, Morris ED. Determination of the In Vivo Selectivity of a New κ-Opioid Receptor Antagonist PET Tracer 11C-LY2795050 in the Rhesus Monkey. Journal Of Nuclear Medicine 2013, 54: 1668-1674. PMID: 23918735, PMCID: PMC5824998, DOI: 10.2967/jnumed.112.118877.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzamidesBrainComputer SimulationImage Interpretation, Computer-AssistedMacaca mulattaMetabolic Clearance RateModels, BiologicalPositron-Emission TomographyPyrrolidinesRadiopharmaceuticalsReceptors, Opioid, kappaReproducibility of ResultsSensitivity and SpecificityTissue Distribution
2010
Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination?
Huang Y, Zheng MQ, Gerdes JM. Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination? Current Topics In Medicinal Chemistry 2010, 10: 1499-526. PMID: 20583995, DOI: 10.2174/156802610793176792.Peer-Reviewed Original ResearchConceptsChemical scaffoldsPositron emission tomographySerotonin transporterTwenty-year journeyImaging tracerFunction of SERTRelated compoundsNon-specific bindingSingle photon emissionRadiotracer developmentSpecific binding signalsPromising radiotracerAlzheimer's diseaseEmission tomographyNeurodegenerative disordersNeuropsychiatric disordersSPECT radiotracerSubstance abusePharmacological propertiesDiseaseScaffoldsTerms of tissueSPECTDiarylsulfidesVivo