2004
Hippocampal theta rhythm is reduced by suppression of the H‐current in septohippocampal GABAergic neurons
Xu C, Datta S, Wu M, Alreja M. Hippocampal theta rhythm is reduced by suppression of the H‐current in septohippocampal GABAergic neurons. European Journal Of Neuroscience 2004, 19: 2299-2309. PMID: 15090056, DOI: 10.1111/j.0953-816x.2004.03316.x.Peer-Reviewed Original ResearchConceptsHippocampal theta rhythmSeptohippocampal GABAergic neuronsGABAergic neuronsTheta rhythmH-currentMedial septum/diagonal bandRat brain slicesCholinergic neuronsGABAergic projectionsLocal infusionSpontaneous firingSelective blockadeDiagonal bandBrain slicesTheta burstsHippocampal learningNeuronsZD7288Underlying mechanismRhythmMemory taskGABAergicHippocampusBlockadeInfusion
2000
Cholinergic Excitation of Septohippocampal GABA But Not Cholinergic Neurons: Implications for Learning and Memory
Wu M, Shanabrough M, Leranth C, Alreja M. Cholinergic Excitation of Septohippocampal GABA But Not Cholinergic Neurons: Implications for Learning and Memory. Journal Of Neuroscience 2000, 20: 3900-3908. PMID: 10804229, PMCID: PMC6772671, DOI: 10.1523/jneurosci.20-10-03900.2000.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAction PotentialsAnimalsAntibodies, MonoclonalCholinergic AgentsCognitionConditioning, PsychologicalElectrophysiologyGamma-Aminobutyric AcidHippocampusImmunotoxinsIn Vitro TechniquesMaleMemoryMuscarineMuscarinic AgonistsN-Glycosyl HydrolasesNeural InhibitionNeuronsRatsRats, Sprague-DawleyReceptor, Nerve Growth FactorReceptors, MuscarinicRibosome Inactivating Proteins, Type 1SaporinsSeptal NucleiSynaptic TransmissionTetrodotoxinTheta RhythmVasodilator AgentsConceptsMedial septum/diagonal bandSeptohippocampal cholinergic neuronsCholinergic neuronsCognition-enhancing effectsMuscarinic agonistsMuscarinic drugsContinuous theta rhythmHippocampal ACh releaseMuscarinic receptor antagonistMuscarinic cholinergic agonistRat brain slicesNovel fluorescent labelling techniqueDouble-labeling techniqueCholinergic excitationSeptohippocampal pathwayAcetylcholine releaseACh releaseDisinhibitory mechanismGABAergic pathwayReceptor antagonistUnlabeled neuronsCholinergic agonistsSystemic administrationDiagonal bandImpulse flow