2004
Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release
Xu C, Michelsen KA, Wu M, Morozova E, Panula P, Alreja M. Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release. The Journal Of Physiology 2004, 561: 657-670. PMID: 15486020, PMCID: PMC1665378, DOI: 10.1113/jphysiol.2004.071712.Peer-Reviewed Original ResearchConceptsLocal ACh releaseACh releaseGABAergic neuronesCholinergic neuronesSeptohippocampal cholinergicMedial septum/diagonal bandHistamine-induced activationGABAergic cell typesReceptor-selective antagonistHippocampal theta rhythmIndirect mechanismsConcentration-dependent mannerAtropine methylbromideHippocampal arousalGABAergic functionHistaminergic systemTuberomammillary nucleusCholinergic systemReceptor subtypesDiagonal bandHistamine effectSelective antagonistAlzheimer's diseaseGABAergic nucleusNeurodegenerative disorders
2000
Muscarinic Tone Sustains Impulse Flow in the Septohippocampal GABA But Not Cholinergic Pathway: Implications for Learning and Memory
Alreja M, Wu M, Liu W, Atkins J, Leranth C, Shanabrough M. Muscarinic Tone Sustains Impulse Flow in the Septohippocampal GABA But Not Cholinergic Pathway: Implications for Learning and Memory. Journal Of Neuroscience 2000, 20: 8103-8110. PMID: 11050132, PMCID: PMC6772717, DOI: 10.1523/jneurosci.20-21-08103.2000.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsAtropineDiagonal Band of BrocaFluorescent DyesGamma-Aminobutyric AcidHippocampusIn Vitro TechniquesLearningMaleMemoryMuscarinic AgonistsMuscarinic AntagonistsNeural PathwaysNeuronsPatch-Clamp TechniquesRatsRats, Sprague-DawleyReceptor, Muscarinic M3Receptors, MuscarinicScopolamineSeptum of BrainSynaptic TransmissionConceptsHippocampal acetylcholine releaseSeptohippocampal cholinergic neuronsMuscarinic toneCholinergic neuronsCholinergic pathwaysAcetylcholine releaseImpulse flowNeurodegenerative disordersCognitive deficitsMedial septum/diagonal bandAmnesic effectMuscarinic cholinergic receptorsRat brain slicesSeptohippocampal cholinergic pathwaySeptohippocampal neuronsDisinhibitory mechanismGABA releaseGABAergic projectionsAxon collateralsCholinergic receptorsGABAergic pathwayMuscarinic receptorsSystemic infusionReceptor agonistSuccessful treatment