2011
Regulation of NKB Pathways and Their Roles in the Control of Kiss1 Neurons in the Arcuate Nucleus of the Male Mouse
Navarro V, Gottsch M, Wu M, García-Galiano D, Hobbs S, Bosch M, Pinilla L, Clifton D, Dearth A, Ronnekleiv O, Braun R, Palmiter R, Tena-Sempere M, Alreja M, Steiner R. Regulation of NKB Pathways and Their Roles in the Control of Kiss1 Neurons in the Arcuate Nucleus of the Male Mouse. Endocrinology 2011, 152: 4265-4275. PMID: 21914775, PMCID: PMC3198996, DOI: 10.1210/en.2011-1143.Peer-Reviewed Original ResearchConceptsGnRH/LH secretionKNDy neuronsKiss1 neuronsGnRH neuronsLH secretionMale miceActions of NKBKiss1-expressing neuronsNegative feedback regulationAdult male miceReceptor-dependent pathwayDynorphin neuronsGonadotropin secretionArcuate nucleusPulsatile secretionDynorphin ANegative feedback effectNKB receptorNKBNeuronsSecretionFeedback regulationKiss1SenktidePutative role
2008
Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons
Dumalska I, Wu M, Morozova E, Liu R, van den Pol A, Alreja M. Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons. Journal Of Neuroscience 2008, 28: 8003-8013. PMID: 18685025, PMCID: PMC2597556, DOI: 10.1523/jneurosci.1225-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBarium CompoundsCapillariesChloridesDiagonal Band of BrocaDrug ResistanceElectrophysiologyFemaleGonadotropin-Releasing HormoneGreen Fluorescent ProteinsIn Vitro TechniquesMaleMedian EminenceMethoxyhydroxyphenylglycolMiceMice, TransgenicNeuronsPotassium ChannelsRatsRats, Sprague-DawleyReceptors, Metabotropic GlutamateRNA, MessengerSynapsesTumor Suppressor ProteinsVesicular Glutamate Transport Protein 2ConceptsMetabotropic glutamate receptor agonistGlutamate receptor agonistsGroup I metabotropic glutamate receptor agonistReceptor agonistGnRH neuronsGonadotropin-Releasing Hormone NeuronsG protein-coupled receptor GPR54Vesicular glutamate transporter 2GnRH-GFP miceRetrograde labeling techniqueGlutamate transporter 2Gonadotropin-releasing hormoneDistinct subpopulationsOnset of pubertyPostpubertal miceHormone neuronsGnRH cellsExcitatory effectsCentral releaseHypogonadotropic hypogonadismPeptide kisspeptinReceptor GPR54Brain slicesNormal pubertyKisspeptin