Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Utilize Insulin Receptor Substrate-2 in Intracellular Signaling*
Argetsinger L, Norstedt G, Billestrup N, White M, Carter-Su C. Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Utilize Insulin Receptor Substrate-2 in Intracellular Signaling*. Journal Of Biological Chemistry 1996, 271: 29415-29421. PMID: 8910607, DOI: 10.1074/jbc.271.46.29415.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsCHO CellsCricetinaeGrowth InhibitorsHuman Growth HormoneHumansInsulin Receptor Substrate ProteinsInterferon-gammaInterleukin-6Intracellular Signaling Peptides and ProteinsLeukemia Inhibitory FactorLymphokinesMicePhosphatidylinositol 3-KinasesPhosphoproteinsPhosphorylationPhosphotransferases (Alcohol Group Acceptor)Signal TransductionTyrosineConceptsInsulin receptor substrate 2Tyrosyl phosphorylationLeukemia inhibitory factorProtein tyrosine phosphatase SHP2Substrate 2JAK2 associationPhosphatase SHP2Regulatory subunitJAK kinasesMaximal phosphorylationTyrosine phosphorylationTyrosine residuesIntracellular signalingPhosphorylationMultiple membersGH receptorInhibitory factorCytokine familyGrowth hormoneReceptorsSHP2KinasePhosphatidylinositolSubstantial signal