Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons*
Burfoot M, Rogers N, Watling D, Smith J, Pons S, Paonessaw G, Pellegrini S, White M, Kerr I. Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons*. Journal Of Biological Chemistry 1997, 272: 24183-24190. PMID: 9305869, DOI: 10.1074/jbc.272.39.24183.Peer-Reviewed Original ResearchConceptsInsulin receptor substrate-1Receptor substrate-1IRS-1IRS proteinsOncostatin MSubstrate-1Protein tyrosine kinasesKinase-dependent activationActivation of phosphatidylinositolJanus kinase (JAK) familyMutant cell linesHuman fibrosarcoma cell lineCell linesInsulin-like growth factor receptorHuman fibrosarcoma cellsKinase familyGrowth factor receptorFibrosarcoma cell lineIRS-2Cytokine receptorsType I interferonJAK1PhosphorylationAntiviral responseFibrosarcoma cells