A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
Schuppin G, Pons S, Hügl S, Aiello L, King G, White M, Rhodes C. A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth. Diabetes 1998, 47: 1074-1085. PMID: 9648831, DOI: 10.2337/diabetes.47.7.1074.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBloodCell DifferentiationCell DivisionDNAGene ExpressionGenes, fosGenes, junInsulin Receptor Substrate ProteinsInsulinomaIntracellular Signaling Peptides and ProteinsIslets of LangerhansMitogensMolecular Sequence DataPancreatic NeoplasmsPhosphoproteinsRatsRetroelementsRNA, MessengerSignal TransductionTumor Cells, CulturedConceptsSignal transduction pathwaysIRS-2 expressionPancreatic beta-cell lineIRS-2Protein kinaseTransduction pathwaysBeta-cell lineGene expressionIRS-2 gene expressionSevenless-1 proteinBeta-cell growthDifferential mRNA display analysisMitogen-activated protein kinaseDifferential gene expressionTyrosine protein kinaseInsulin receptor substrate 2Insulinoma cellsInsulin receptor substrateGene candidate approachSerum-stimulated DNA synthesisPancreatic beta-cell growthRibosomal proteinsProtein complexesMRNA levelsBeta-cells contributes