Early biochemical events in insulin-stimulated fluid phase endocytosis
Pitterle D, Sperling R, Myers M, White M, Blackshear P. Early biochemical events in insulin-stimulated fluid phase endocytosis. American Journal Of Physiology 1999, 276: e94-e105. PMID: 9886955, DOI: 10.1152/ajpendo.1999.276.1.e94.Peer-Reviewed Original ResearchConceptsInsulin receptor substrate-1Fluid-phase endocytosisMitogen-activated protein kinase kinaseRat-1 cellsInsulin receptorDominant negative mutant RasHematopoietic precursor cell lineBat cellsHIRc-B cellsInhibitor of PIProtein kinase kinaseWild-type RasMEK inhibitor PD 98059Active insulin receptorEndogenous IRS-1Receptor substrate-1Inhibitor PD 98059Certain cell typesPrecursor cell lineInitial molecular mechanismsIRS-1 expressionKinase kinaseEarly biochemical eventsMutant RasSubstrate-1