Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling
Withers D, Burks D, Towery H, Altamuro S, Flint C, White M. Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling. Nature Genetics 1999, 23: 32-40. PMID: 10471495, DOI: 10.1038/12631.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsApoptosisBlood GlucoseBody WeightFemaleGene Expression Regulation, DevelopmentalGlucose Tolerance TestInsulinInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsIslets of LangerhansLiverMaleMiceMice, KnockoutMuscle, SkeletalPancreasPhosphoproteinsReceptor, IGF Type 1Signal TransductionTime FactorsConceptsIGF-1 receptorΒ-cell developmentIGF-1Glucose homeostasisΒ-cellsPeripheral insulin resistancePeripheral target tissuesEffect of insulinPancreatic β-cellsPeripheral insulinInsulin resistanceInsulin receptor substratePost-natal growthGlucose metabolismNull allelesTarget tissuesInsulinMiceReceptor substrateIR-1Carbohydrate metabolismReceptorsSurvivalCell growthPleiotropic effects