2014
IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity
White M. IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity. Diabetes Obesity And Metabolism 2014, 16: 4-15. PMID: 25200290, DOI: 10.1111/dom.12347.Peer-Reviewed Original ResearchConceptsInsulin/IGF1Central nervous systemInsulin-like signalingLife spanOrganisms showsCellular functionsNutrient homeostasisInsulin resistanceGenetic manipulationSystemic insulin resistanceClinical Alzheimer's diseaseType 2 diabetesEnergy homeostasisNeurodegenerative diseasesMetabolismNeurodegenerationCompensatory hyperinsulinaemiaHomeostasisProgressive neurodegenerationSystemic metabolismIGF1Excess insulinNervous systemAlzheimer's diseaseClinical perspective
2012
Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling
Sadagurski M, White M. Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling. Endocrinology And Metabolism Clinics Of North America 2012, 42: 127-148. PMID: 23391244, PMCID: PMC3982789, DOI: 10.1016/j.ecl.2012.11.008.Peer-Reviewed Original ResearchConceptsInsulin/IGF1Central nervous systemLife spanOrganism longevityCellular functionsStress resistanceGenetic manipulationIGF1 signalingInsulin pathwayMetabolic homeostasisEnergy homeostasisPeripheral energy homeostasisSystemic insulin resistanceHomeostasisMetabolismSystemic metabolismNeuronal circuitsCompensatory hyperinsulinemiaInsulin resistanceIGF1Central regulationExcess insulinNervous systemLongevityNematodes
2000
IRS-2 pathways integrate female reproduction and energy homeostasis
Burks D, de Mora J, Schubert M, Withers D, Myers M, Towery H, Altamuro S, Flint C, White M. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 2000, 407: 377-382. PMID: 11014193, DOI: 10.1038/35030105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEnergy IntakeEnergy MetabolismEstrusFemaleFertilityGonadal Steroid HormonesHomeostasisInfertilityInsulinInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsLeptinLuteinizing HormoneMaleMiceMice, Inbred C57BLMice, KnockoutOvaryPhosphoproteinsPituitary GlandReceptor, InsulinReproductionSignal TransductionSteroidsConceptsInsulin receptor substrate 2Insulin/insulin-like growth factor-1Insulin-signaling pathwayEnergy homeostasisC. elegansIRS-2 pathwayLower organismsSubstrate 2Female reproductionRegulation of fertilityMetabolic signalsInsulin-like growth factor-1Reproductive statusFactor 1Infertile conditionsSevere dietary restrictionMammalsGrowth factor-1HomeostasisReproductionAnovulatory ovariesHypothalamic controlFemale infertilityPlasma concentrationsCatabolic state