Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*
Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI. Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle*. Journal Of Biological Chemistry 2002, 277: 50230-50236. PMID: 12006582, DOI: 10.1074/jbc.m200958200.Peer-Reviewed Original ResearchConceptsIRS-1 tyrosine phosphorylationInsulin receptor substrate-1PI3-kinase activityReceptor substrate-1IRS-1Tyrosine phosphorylationSubstrate-1Insulin activationIRS-1-associated PI3-kinase activityInsulin-stimulated IRS-1 tyrosine phosphorylationInsulin-stimulated glucose transport activityProtein kinase CGlucose transport activityFatty acidsLipid infusionFatty acyl-CoAsDAG concentrationKinase CTransport activityPKC-thetaPhosphorylationIntracellular ceramideAcyl-CoAsTime-dependent fashionPhosphatidylinositol