2015
Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays
Stoiljkovic M, Leventhal L, Chen A, Chen T, Driscoll R, Flood D, Hodgdon H, Hurst R, Nagy D, Piser T, Tang C, Townsend M, Tu Z, Bertrand D, Koenig G, Hajós M. Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays. Biochemical Pharmacology 2015, 97: 576-589. PMID: 26206187, DOI: 10.1016/j.bcp.2015.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnimalsBehavior, AnimalCHO CellsCricetinaeCricetulusDose-Response Relationship, DrugFemaleGene Expression RegulationHippocampusHumansLearningMaleMemoryMiceMice, Inbred C57BLOocytesProtein BindingQuinuclidinesRatsRats, Sprague-DawleyRats, WistarThiophenesXenopus laevisConceptsHippocampal theta oscillationsTheta oscillationsNeurophysiological assaysPro-cognitive effectsNovel object recognitionStimulation-induced hippocampal theta oscillationTheta oscillation powerWater T-mazeCognitive effectsNeurophysiological correlatesDose-dependent facilitationMemory acquisitionCognitive functionT-mazeObject recognitionΑ7 nAChRsHuman α7 nAChRConcentration-response relationshipSynaptic transmissionΑ7 nicotinic acetylcholine receptorSub-maximal concentrationsRat hippocampal slicesLong-term potentiationNicotinic acetylcholine receptorsOscillation power
2014
Application of neurophysiological biomarkers for Huntington's disease: Evaluating a phosphodiesterase 9A inhibitor
Nagy D, Tingley FD, Stoiljkovic M, Hajós M. Application of neurophysiological biomarkers for Huntington's disease: Evaluating a phosphodiesterase 9A inhibitor. Experimental Neurology 2014, 263: 122-131. PMID: 25315303, DOI: 10.1016/j.expneurol.2014.10.001.Peer-Reviewed Original ResearchMeSH Keywords3',5'-Cyclic-AMP PhosphodiesterasesAcoustic StimulationAnimalsAuditory CortexDisease Models, AnimalElectrophysiologyEnzyme InhibitorsEvoked Potentials, AuditoryHippocampusHuntington DiseaseMiceMice, Inbred C57BLMice, TransgenicPyrazolesPyrimidinonesRatsRats, Sprague-DawleyRats, TransgenicSensory GatingConceptsBACHD transgenic ratsPrimary auditory cortexAuditory gatingDisease patientsHuntington's diseaseAuditory cortexBACHD ratsTransgenic ratsPF-04447943Sub-chronic treatmentPotential translational biomarkersHuntington's disease patientsTransgenic animal modelsBasic neuropathologyDaily administrationTranslational biomarkersQ175 miceNeurophysiological abnormalitiesSystemic administrationNeurophysiological biomarkersLast treatmentAnimal modelsTransgenic miceGamma band powerBrain regions