Modulation of hippocampal neuronal network oscillations by α7 nACh receptors
Stoiljkovic M, Kelley C, Nagy D, Hajós M. Modulation of hippocampal neuronal network oscillations by α7 nACh receptors. Biochemical Pharmacology 2015, 97: 445-453. PMID: 26206189, DOI: 10.1016/j.bcp.2015.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnimalsGene Expression RegulationHippocampusNerve NetConceptsNucleus pontis oralisNeuronal network oscillationsΑ7 nAChRsHippocampal oscillationsNetwork oscillationsBrainstem nucleus pontis oralisHippocampal-dependent cognitive functionsHippocampal thetaTheta-phase gamma-amplitude couplingΑ7 nicotinic acetylcholine receptorHigh-frequency stimulationΑ7 nACh receptorsNicotinic acetylcholine receptorsNeuronal network activityNetwork activityPyramidal neuronsFrequency stimulationPontis oralisPharmacological effectsPreclinical screeningNACh receptorsAcetylcholine receptorsSuch drugsCognitive functionHippocampusConcentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays
Stoiljkovic M, Leventhal L, Chen A, Chen T, Driscoll R, Flood D, Hodgdon H, Hurst R, Nagy D, Piser T, Tang C, Townsend M, Tu Z, Bertrand D, Koenig G, Hajós M. Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays. Biochemical Pharmacology 2015, 97: 576-589. PMID: 26206187, DOI: 10.1016/j.bcp.2015.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnimalsBehavior, AnimalCHO CellsCricetinaeCricetulusDose-Response Relationship, DrugFemaleGene Expression RegulationHippocampusHumansLearningMaleMemoryMiceMice, Inbred C57BLOocytesProtein BindingQuinuclidinesRatsRats, Sprague-DawleyRats, WistarThiophenesXenopus laevisConceptsHippocampal theta oscillationsTheta oscillationsNeurophysiological assaysPro-cognitive effectsNovel object recognitionStimulation-induced hippocampal theta oscillationTheta oscillation powerWater T-mazeCognitive effectsNeurophysiological correlatesDose-dependent facilitationMemory acquisitionCognitive functionT-mazeObject recognitionΑ7 nAChRsHuman α7 nAChRConcentration-response relationshipSynaptic transmissionΑ7 nicotinic acetylcholine receptorSub-maximal concentrationsRat hippocampal slicesLong-term potentiationNicotinic acetylcholine receptorsOscillation power