2018
Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology
Stoiljkovic M, Kelley C, Stutz B, Horvath TL, Hajós M. Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer’s Disease Pathology. Cerebral Cortex 2018, 29: 2716-2727. PMID: 29920597, PMCID: PMC7302691, DOI: 10.1093/cercor/bhy140.Peer-Reviewed Original ResearchConceptsTgF344-AD ratsHippocampal theta oscillationsAlzheimer's diseaseDisease pathologyTheta-phase gamma-amplitude couplingAge-matched wild-type counterpartsAD pathological featuresDisease-modifying therapiesAccumulation of amyloidPredictive animal modelsAlzheimer's disease pathologyHigh-voltage spindlesTheta oscillationsSignificant age-dependent declineAge-dependent declineHippocampal excitabilitySharp-wave ripplesAβ accumulationNeuronal lossAD ratsPathological featuresUrethane anesthesiaAD patientsAuditory gatingAD drugs
2016
Activation of α7 nicotinic acetylcholine receptors facilitates long-term potentiation at the hippocampal-prefrontal cortex synapses in vivo
Stoiljkovic M, Kelley C, Nagy D, Hurst R, Hajós M. Activation of α7 nicotinic acetylcholine receptors facilitates long-term potentiation at the hippocampal-prefrontal cortex synapses in vivo. European Neuropsychopharmacology 2016, 26: 2018-2023. PMID: 27866776, DOI: 10.1016/j.euroneuro.2016.11.003.Peer-Reviewed Original ResearchConceptsHippocampal-medial prefrontal cortex pathwayHippocampal-prefrontal cortex pathwayLong-term potentiationPrefrontal cortex pathwayCognitive processesCortex pathwayCognitive effectsMnemonic functionsCognitive functionMemory formationNeurophysiological effectsΑ7-nAChR activationNAChR activationΑ7 nAChRsHippocampal long-term potentiationSubiculum regionsΑ7 nicotinic acetylcholine receptorNicotinic acetylcholine receptorsMale ratsSaline controlsSynaptic transmissionBrain slicesTetanic stimulationAcetylcholine receptorsSynaptic plasticity
2015
Differential Effects of an NR2B NAM and Ketamine on Synaptic Potentiation and Gamma Synchrony: Relevance to Rapid-Onset Antidepressant Efficacy
Nagy D, Stoiljkovic M, Menniti FS, Hajós M. Differential Effects of an NR2B NAM and Ketamine on Synaptic Potentiation and Gamma Synchrony: Relevance to Rapid-Onset Antidepressant Efficacy. Neuropsychopharmacology 2015, 41: 1486-1494. PMID: 26404843, PMCID: PMC4832008, DOI: 10.1038/npp.2015.298.Peer-Reviewed Original ResearchConceptsAuditory-evoked potentialsAntidepressant effectsSynaptic potentiationAntidepressant efficacyAuditory gatingRapid-onset antidepressant effectsEffects of ketaminePrimary auditory cortexReceptor channel blockerDifferent acute effectsNMDA receptor inhibitionNegative allosteric modulatorsPotential mechanistic underpinningsReceptor inhibitionSystemic administrationAcute effectsNeurophysiological biomarkersTranslatable biomarkersChannel blockersDrug eliminationAuditory cortexNeurophysiological parametersDrug AdministrationGamma band powerKetamineConcentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays
Stoiljkovic M, Leventhal L, Chen A, Chen T, Driscoll R, Flood D, Hodgdon H, Hurst R, Nagy D, Piser T, Tang C, Townsend M, Tu Z, Bertrand D, Koenig G, Hajós M. Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays. Biochemical Pharmacology 2015, 97: 576-589. PMID: 26206187, DOI: 10.1016/j.bcp.2015.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnimalsBehavior, AnimalCHO CellsCricetinaeCricetulusDose-Response Relationship, DrugFemaleGene Expression RegulationHippocampusHumansLearningMaleMemoryMiceMice, Inbred C57BLOocytesProtein BindingQuinuclidinesRatsRats, Sprague-DawleyRats, WistarThiophenesXenopus laevisConceptsHippocampal theta oscillationsTheta oscillationsNeurophysiological assaysPro-cognitive effectsNovel object recognitionStimulation-induced hippocampal theta oscillationTheta oscillation powerWater T-mazeCognitive effectsNeurophysiological correlatesDose-dependent facilitationMemory acquisitionCognitive functionT-mazeObject recognitionΑ7 nAChRsHuman α7 nAChRConcentration-response relationshipSynaptic transmissionΑ7 nicotinic acetylcholine receptorSub-maximal concentrationsRat hippocampal slicesLong-term potentiationNicotinic acetylcholine receptorsOscillation power
2014
Application of neurophysiological biomarkers for Huntington's disease: Evaluating a phosphodiesterase 9A inhibitor
Nagy D, Tingley FD, Stoiljkovic M, Hajós M. Application of neurophysiological biomarkers for Huntington's disease: Evaluating a phosphodiesterase 9A inhibitor. Experimental Neurology 2014, 263: 122-131. PMID: 25315303, DOI: 10.1016/j.expneurol.2014.10.001.Peer-Reviewed Original ResearchMeSH Keywords3',5'-Cyclic-AMP PhosphodiesterasesAcoustic StimulationAnimalsAuditory CortexDisease Models, AnimalElectrophysiologyEnzyme InhibitorsEvoked Potentials, AuditoryHippocampusHuntington DiseaseMiceMice, Inbred C57BLMice, TransgenicPyrazolesPyrimidinonesRatsRats, Sprague-DawleyRats, TransgenicSensory GatingConceptsBACHD transgenic ratsPrimary auditory cortexAuditory gatingDisease patientsHuntington's diseaseAuditory cortexBACHD ratsTransgenic ratsPF-04447943Sub-chronic treatmentPotential translational biomarkersHuntington's disease patientsTransgenic animal modelsBasic neuropathologyDaily administrationTranslational biomarkersQ175 miceNeurophysiological abnormalitiesSystemic administrationNeurophysiological biomarkersLast treatmentAnimal modelsTransgenic miceGamma band powerBrain regions
2008
Local antagonism of intertrigeminal region metabotropic glutamate receptors exacerbates apneic responses to intravenous serotonin
Stoiljkovic M, Radulovacki M, Carley D. Local antagonism of intertrigeminal region metabotropic glutamate receptors exacerbates apneic responses to intravenous serotonin. Respiratory Physiology & Neurobiology 2008, 165: 137-142. PMID: 19026767, PMCID: PMC2773821, DOI: 10.1016/j.resp.2008.10.019.Peer-Reviewed Original ResearchConceptsIntravenous serotonin infusionMetabotropic glutamate receptorsIntertrigeminal regionSerotonin infusionReceptor antagonistGlutamate receptorsBroad-spectrum glutamate receptor antagonistType 1 metabotropic glutamate receptorMetabotropic glutamate antagonistPontine intertrigeminal regionVagal afferent pathwaysDuration of apneaGlutamate receptor antagonistsAMPA receptor antagonistDose-dependent fashionRespiratory pattern changesApnea expressionApneic responseIntravenous serotoninSpontaneous apneasReflex apneaRespiratory dysrhythmiaAfferent pathwaysIntravenous infusionGlutamate antagonists
2006
Effects of intertrigeminal region NMDA and non-NMDA receptors on respiratory responses in rats
Radulovacki M, Stoiljkovic M, Saponjic J, Carley D. Effects of intertrigeminal region NMDA and non-NMDA receptors on respiratory responses in rats. Respiratory Physiology & Neurobiology 2006, 156: 40-46. PMID: 16934539, DOI: 10.1016/j.resp.2006.07.005.Peer-Reviewed Original ResearchConceptsNon-NMDA receptorsIntertrigeminal regionNMDA receptorsReflex apneaNonspecific glutamate receptor antagonist kynurenic acidGlutamate receptor antagonist kynurenic acidSpecific NMDA receptor antagonistRespiratory responsesAntagonist kynurenic acidVentral respiratory groupMicroinjection of glutamateNMDA receptor antagonistSleep-related apneaLong-term potentiationFunctional NMDA receptorsImmediate apneaVagal reflexGlutamate injectionRespiratory groupRespiratory disturbancesKynurenic acidReceptor antagonistSelective blockadeApneaLateral pons