2008
Local antagonism of intertrigeminal region metabotropic glutamate receptors exacerbates apneic responses to intravenous serotonin
Stoiljkovic M, Radulovacki M, Carley D. Local antagonism of intertrigeminal region metabotropic glutamate receptors exacerbates apneic responses to intravenous serotonin. Respiratory Physiology & Neurobiology 2008, 165: 137-142. PMID: 19026767, PMCID: PMC2773821, DOI: 10.1016/j.resp.2008.10.019.Peer-Reviewed Original ResearchConceptsIntravenous serotonin infusionMetabotropic glutamate receptorsIntertrigeminal regionSerotonin infusionReceptor antagonistGlutamate receptorsBroad-spectrum glutamate receptor antagonistType 1 metabotropic glutamate receptorMetabotropic glutamate antagonistPontine intertrigeminal regionVagal afferent pathwaysDuration of apneaGlutamate receptor antagonistsAMPA receptor antagonistDose-dependent fashionRespiratory pattern changesApnea expressionApneic responseIntravenous serotoninSpontaneous apneasReflex apneaRespiratory dysrhythmiaAfferent pathwaysIntravenous infusionGlutamate antagonists
2006
Effects of intertrigeminal region NMDA and non-NMDA receptors on respiratory responses in rats
Radulovacki M, Stoiljkovic M, Saponjic J, Carley D. Effects of intertrigeminal region NMDA and non-NMDA receptors on respiratory responses in rats. Respiratory Physiology & Neurobiology 2006, 156: 40-46. PMID: 16934539, DOI: 10.1016/j.resp.2006.07.005.Peer-Reviewed Original ResearchConceptsNon-NMDA receptorsIntertrigeminal regionNMDA receptorsReflex apneaNonspecific glutamate receptor antagonist kynurenic acidGlutamate receptor antagonist kynurenic acidSpecific NMDA receptor antagonistRespiratory responsesAntagonist kynurenic acidVentral respiratory groupMicroinjection of glutamateNMDA receptor antagonistSleep-related apneaLong-term potentiationFunctional NMDA receptorsImmediate apneaVagal reflexGlutamate injectionRespiratory groupRespiratory disturbancesKynurenic acidReceptor antagonistSelective blockadeApneaLateral pons