2022
TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice
Stoiljkovic M, Gutierrez KO, Kelley C, Horvath TL, Hajós M. TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice. Journal Of Alzheimer's Disease 2022, 88: 837-847. PMID: 34120899, PMCID: PMC8898080, DOI: 10.3233/jad-210041.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseMicroglial functionTREM2 functionTheta-phase gamma-amplitude couplingHippocampal network functionSpontaneous epileptiform seizuresNetwork oscillationsTransgenic AD modelHippocampal neuronal excitabilityMyeloid cells 2Clinical Alzheimer's diseaseWild-type miceHippocampal network oscillationsHippocampal pathophysiologyProgressive dementiaTau pathologyUrethane anesthesiaAD pathophysiologyNeuronal excitabilityEpileptiform seizuresEpileptic activityAD modelTREM2Disease pathologyCells 2
2015
Modulation of hippocampal neuronal network oscillations by α7 nACh receptors
Stoiljkovic M, Kelley C, Nagy D, Hajós M. Modulation of hippocampal neuronal network oscillations by α7 nACh receptors. Biochemical Pharmacology 2015, 97: 445-453. PMID: 26206189, DOI: 10.1016/j.bcp.2015.06.031.Peer-Reviewed Original ResearchConceptsNucleus pontis oralisNeuronal network oscillationsΑ7 nAChRsHippocampal oscillationsNetwork oscillationsBrainstem nucleus pontis oralisHippocampal-dependent cognitive functionsHippocampal thetaTheta-phase gamma-amplitude couplingΑ7 nicotinic acetylcholine receptorHigh-frequency stimulationΑ7 nACh receptorsNicotinic acetylcholine receptorsNeuronal network activityNetwork activityPyramidal neuronsFrequency stimulationPontis oralisPharmacological effectsPreclinical screeningNACh receptorsAcetylcholine receptorsSuch drugsCognitive functionHippocampus