Local antagonism of intertrigeminal region metabotropic glutamate receptors exacerbates apneic responses to intravenous serotonin
Stoiljkovic M, Radulovacki M, Carley D. Local antagonism of intertrigeminal region metabotropic glutamate receptors exacerbates apneic responses to intravenous serotonin. Respiratory Physiology & Neurobiology 2008, 165: 137-142. PMID: 19026767, PMCID: PMC2773821, DOI: 10.1016/j.resp.2008.10.019.Peer-Reviewed Original ResearchConceptsIntravenous serotonin infusionMetabotropic glutamate receptorsIntertrigeminal regionSerotonin infusionReceptor antagonistGlutamate receptorsBroad-spectrum glutamate receptor antagonistType 1 metabotropic glutamate receptorMetabotropic glutamate antagonistPontine intertrigeminal regionVagal afferent pathwaysDuration of apneaGlutamate receptor antagonistsAMPA receptor antagonistDose-dependent fashionRespiratory pattern changesApnea expressionApneic responseIntravenous serotoninSpontaneous apneasReflex apneaRespiratory dysrhythmiaAfferent pathwaysIntravenous infusionGlutamate antagonists