Selective activation of α7 nicotinic acetylcholine receptors augments hippocampal oscillations
Stoiljkovic M, Kelley C, Nagy D, Leventhal L, Hajós M. Selective activation of α7 nicotinic acetylcholine receptors augments hippocampal oscillations. Neuropharmacology 2016, 110: 102-108. PMID: 27422408, DOI: 10.1016/j.neuropharm.2016.07.010.Peer-Reviewed Original ResearchConceptsΑ7 nicotinic acetylcholine receptorNicotinic acetylcholine receptorsΑ7 nAChRsHippocampal oscillationsPNU-282987Acetylcholine receptorsAlzheimer's diseasePotential pharmacologic targetWild-type miceSelective activationNeuronal network oscillationsTheta powerΑ7KO miceHippocampal theta oscillationsClinical evidenceControl micePreclinical observationsUrethane anesthesiaProcognitive activityProcognitive effectsPharmacologic targetAgonistsCognitive deficitsHippocampal activityΑ7Hippocampal network dynamics in response to α7 nACh receptors activation in amyloid-β overproducing transgenic mice
Stoiljkovic M, Kelley C, Hajós GP, Nagy D, Koenig G, Leventhal L, Hajós M. Hippocampal network dynamics in response to α7 nACh receptors activation in amyloid-β overproducing transgenic mice. Neurobiology Of Aging 2016, 45: 161-168. PMID: 27459936, DOI: 10.1016/j.neurobiolaging.2016.05.021.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseΑ7 nicotinic acetylcholine receptorEffect of α7Wild-type miceGamma oscillationsNicotinic acetylcholine receptorsHippocampal network dynamicsSymptomatic treatmentClinical findingsAD patientsSaline controlsProcognitive drugsΑ7 nAChRsTransgenic miceAcetylcholine receptorsReceptor activationCognitive functionHippocampal oscillationsMiceNeurophysiological impairmentsAgonistsPower of thetaΑ7AβSignificant differences