2012
Differential effects of age on human striatal adenosine A1 and A2A receptors
Mishina M, Kimura Y, Naganawa M, Ishii K, Oda K, Sakata M, Toyohara J, Kobayashi S, Katayama Y, Ishiwata K. Differential effects of age on human striatal adenosine A1 and A2A receptors. Synapse 2012, 66: 832-839. PMID: 22623181, DOI: 10.1002/syn.21573.Peer-Reviewed Original ResearchConceptsDistribution volume ratioEffect of ageCaudate nucleusPET scanningAge-related decreaseElderly subjectsElderly volunteersAdenosine A1Healthy subjectsPET scansA2A receptorsYoung subjectsHuman striatumStriatumReceptorsAgePutamenDifferential effectsPrevious reportsSubjectsAdenosineDistribution of adenosinePropylxanthineHead
2011
Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients
Mishina M, Ishiwata K, Naganawa M, Kimura Y, Kitamura S, Suzuki M, Hashimoto M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kobayashi S, Katayama Y, Ishii K. Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients. PLOS ONE 2011, 6: e17338. PMID: 21386999, PMCID: PMC3046146, DOI: 10.1371/journal.pone.0017338.Peer-Reviewed Original ResearchConceptsDrug-naïve patientsDrug-naïve PD patientsPositron emission tomographyPD patientsParkinson's diseaseAntiparkinsonian therapyControl subjectsAffected sideDisease patientsCaudate nucleusParkinson's disease patientsElderly control subjectsNormal control subjectsSelective A2AR antagonistAdenosine A2A receptorsDistribution volume ratioMild dyskinesiaA2AR antagonistDopaminergic systemBilateral putamenPET scansPatientsA2A receptorsNovel treatmentsPutamen
2007
Robust estimation of the arterial input function for Logan plots using an intersectional searching algorithm and clustering in positron emission tomography for neuroreceptor imaging
Naganawa M, Kimura Y, Yano J, Mishina M, Yanagisawa M, Ishii K, Oda K, Ishiwata K. Robust estimation of the arterial input function for Logan plots using an intersectional searching algorithm and clustering in positron emission tomography for neuroreceptor imaging. NeuroImage 2007, 40: 26-34. PMID: 18187345, DOI: 10.1016/j.neuroimage.2007.11.035.Peer-Reviewed Original ResearchEvaluation of distribution of adenosine A2A receptors in normal human brain measured with [11C]TMSX PET
Mishina M, Ishiwata K, Kimura Y, Naganawa M, Oda K, Kobayashi S, Katayama Y, Ishii K. Evaluation of distribution of adenosine A2A receptors in normal human brain measured with [11C]TMSX PET. Synapse 2007, 61: 778-784. PMID: 17568431, DOI: 10.1002/syn.20423.Peer-Reviewed Original ResearchConceptsPositron emission tomographyPosterior putamenCaudate nucleusFrontal lobeHuman brainPromising PET ligandSelective A2AR antagonistNormal male subjectsMetabolite-corrected plasmaPosterior cingulate gyrusAdenosine A2A receptorsNormal human brainCerebral cortexA2AR antagonistCingulate gyrusArterial bloodOccipital lobeParkinson's diseaseTemporal lobePET scansA2A receptorsThree-compartment modelParietal lobePET ligandMale subjects
2006
Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography
Naganawa M, Kimura Y, Mishina M, Manabe Y, Chihara K, Oda K, Ishii K, Ishiwata K. Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography. European Journal Of Nuclear Medicine And Molecular Imaging 2006, 34: 679-687. PMID: 17171358, DOI: 10.1007/s00259-006-0294-0.Peer-Reviewed Original Research
2005
Omission of serial arterial blood sampling in neuroreceptor imaging with independent component analysis
Naganawa M, Kimura Y, Nariai T, Ishii K, Oda K, Manabe Y, Chihara K, Ishiwata K. Omission of serial arterial blood sampling in neuroreceptor imaging with independent component analysis. NeuroImage 2005, 26: 885-890. PMID: 15955498, DOI: 10.1016/j.neuroimage.2005.02.025.Peer-Reviewed Original ResearchConceptsArterial blood samplingBlood samplingCerebral glucose metabolismAdenosine A1 receptorsTotal distribution volumeSerial arterial blood samplingLogan plotPET imagesPlasma time-activity curveA1 receptorsHealthy subjectsGlucose metabolismTime-activity curvesDistribution volumeBrain diseasesDVTReference regionSubjectsParametric imagesDynamic PET images