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Mihir Gupta, MD

Assistant Professor
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Assistant Professor

Biography

Dr. Mihir Gupta is a fellowship-trained spine surgeon and assistant professor of neurosurgery. After graduating from Stanford University, he completed neurosurgical residency at the University of California San Diego, postdoctoral studies at Harvard Medical School, and orthopedic spine surgery fellowship at Johns Hopkins University. With a background in both neurosurgery and orthopedics, he performs a variety of traditional as well as minimally invasive procedures for a variety of complex spinal disorders. Dr. Gupta prioritizes understanding each patient's unique and detailed story. He works closely with physical therapists, pain specialists and physiatrists to offer personalized surgical and non-surgical treatments.

Appointments

Other Departments & Organizations

Education & Training

Fellow, Complex Spine Surgery
Johns Hopkins University
Resident Physician
University of California San Diego
Postdoctoral Fellow
Massachusetts General Hospital
MD
Stanford University School of Medicine
BA
Harvard College

Research

Research at a Glance

Publications Timeline

A big-picture view of Mihir Gupta's research output by year.
16Publications
217Citations

Publications

2024

  • Rapid Tumor DNA Analysis of Cerebrospinal Fluid Accelerates Treatment of Central Nervous System Lymphoma.
    Gupta M, Bradley J, Massaad E, Burns E, Georgantas NZ, Maron G, Batten J, Gallagher A, Thierauf J, Nayyar N, Gordon A, Jones S, Pisapia M, Sun Y, Jones PS, Barker FG 2nd, Curry W, Gupta R, Romero J, Wang N, Brastianos P, Martinez-Lage M, Tateishi K, Forst DA, Nahed BV, Batchelor TT, Ritterhouse LL, Iser F, Kessler T, Jordan JT, Dietrich J, Meyerson ML, Cahill DP, Lennerz JK, Carter B, Shankar GM. Rapid Tumor DNA Analysis of Cerebrospinal Fluid Accelerates Treatment of Central Nervous System Lymphoma. Blood 2024 PMID: 38776489, DOI: 10.1182/blood.2024023832.
    Peer-Reviewed Original Research
  • Radical surgical resection with molecular margins is associated with improved survival in IDH wildtype GBM.
    Massaad E, Smith WJ, Bradley J, Esposito E, Gupta M, Burns E, Burns R, Velarde JK, Berglar IK, Gupta R, Martinez-Lage M, Dietrich J, Lennerz JK, Dunn GP, Jones PS, Choi BD, Kim AE, Frosch M, Barker FG 2nd, Curry WT, Carter BS, Nahed BV, Cahill DP, Shankar GM. Radical surgical resection with molecular margins is associated with improved survival in IDH wildtype GBM. Neuro Oncol 2024 PMID: 38581292, DOI: 10.1093/neuonc/noae073.
    Peer-Reviewed Original Research

2023

  • Human microglia maturation is underpinned by specific gene regulatory networks.
    Han CZ, Li RZ, Hansen E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O'Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA, Birth Defects Research Laboratory, Levy ML, Haim SB, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG. Human microglia maturation is underpinned by specific gene regulatory networks. Immunity 2023, 56: 2152-2171.e13. PMID: 37582369, DOI: 10.1016/j.immuni.2023.07.016.
    Peer-Reviewed Original Research
  • Cerebrospinal Fluid Genotyping Accelerates Brain Tumor Patient Treatment
    Gupta M, Bradley JD, Massaad E, Burns EJ, Georgantas NZ, Maron GE, Thierauf J, Nayyar N, Gordon A, Jones SS, Pisapia M, Sun Y, Jones PS, Barker FG, Curry WT, Gupta R, Romero JM, Wang N, Brastianos PK, Martinez-Lage M, Tateishi K, Forst DA, Nahed BV, Batchelor TT, Ritterhouse LL, Jordan JT, Dietrich J, Meyerson M, Cahill DP, Lennerz JK, Carter BS, Shankar GM. [under review]
    Peer-Reviewed Original Research

2021

2020

Clinical Care

Overview

Mihir Gupta, MD, is a fellowship-trained spine surgeon with a background in neurosurgery and orthopaedics. He performs both traditional and minimally invasive procedures to treat an array of complex spinal disorders.

Dr. Gupta says he was drawn to spine surgery because of how quickly the field is evolving. “We finally have a much better understanding of why people have back or neck pain and how to make it better safely,” he says. “And that doesn’t always involve surgery. Our job is to figure out when surgery is appropriate, and more importantly, when it is not the best solution.”

Dr. Gupta treats a variety of spine conditions including those that are degenerative, deformative, or the result of tumors, infections, or trauma. He also performs revision spine surgeries, or surgeries for people who have had surgery in the past but have a persistent or new problem.

Before he walks in the exam room and meets a new patient, Dr. Gupta says he likes to do his homework and look through any imaging studies they brought. “That way, I can focus on listening to them and doing a very thorough physical exam,” he says. “A thoughtful evaluation and really good physical exam are vital for making an accurate diagnosis. Often, I think patients haven’t had their problem explained in a way that makes sense to them, and I prioritize that.”

Spine procedures, Dr. Gupta says, are highly personalized. “There isn’t a one-size-fits-all approach. Our diagnostics have come so far that we have better imaging that allows us to see where pain is coming from and if surgery is needed,” Dr. Gupta says. “We also have better tools now with robotics and navigation and minimally invasive methods. These all allow us to tailor the right solution for them.”

Surgery, he points out, is often the last resort and, in some cases, is not the right solution for a patient’s pain. “We work closely with the pain management team, anesthesiology, physical therapists, and interventional radiologists to come up with nonsurgical options,” he says.

Dr. Gupta’s research interests include understanding how genetics contribute to different spinal disorders and how care can be personalized.

Clinical Specialties

Neurosurgery

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