2020
Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J
Cueto A, Álvarez L, García M, Artime E, Barrios A, Rodríguez-Uña I, Coca-Prados M, González-Iglesias H. Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J. Diagnostics 2020, 10: 425. PMID: 32585848, PMCID: PMC7345206, DOI: 10.3390/diagnostics10060425.Peer-Reviewed Original ResearchImmune responseSystemic levelsOptic nerve damageImportant molecular changesDiagnosis of glaucomaComplement factor HCandidate molecular biomarkersGlaucomatous miceAdvanced diseaseNerve damageControl miceGlaucoma developmentComplement system proteinsSystemic alterationsDBA/2J miceAnimal modelsComplement C4AFicolin-3Potential biomarkersDifferent experimental groupsEnzyme immunoassayApolipoprotein A4Neurodegenerative diseasesGlaucomaSerum samples
1994
Isolation of cDNA clones encoding the 80-kd subunit protein of the human autoantigen Ku (p70/p80) by antisera raised against ciliary processes of human eye donors.
Hong T, Escribano J, Coca-Prados M. Isolation of cDNA clones encoding the 80-kd subunit protein of the human autoantigen Ku (p70/p80) by antisera raised against ciliary processes of human eye donors. Investigative Ophthalmology & Visual Science 1994, 35: 4023-30. PMID: 7960584.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, NuclearAutoantigensBlotting, WesternCell LineCiliary BodyClone CellsDNA HelicasesDNA, ComplementaryDNA-Binding ProteinsFluorescent Antibody TechniqueHumansImmunoglobulin GKu AutoantigenMaleMiceMice, Inbred BALB CMiddle AgedMolecular WeightNuclear ProteinsPigment Epithelium of EyeRNA, MessengerTissue DonorsConceptsHuman eye donorsPolymyositis overlap syndromeScleroderma-polymyositis overlap syndromeODM-2 cellsHuman ciliary processesCiliary processesOverlap syndromeEye donorsCiliary epitheliumSpecies-specific immune responseAnti-Ku antibodiesVariety of antigensCell linesEpithelium cell linePlaque-purified clonesCiliary epithelial cell lineOcular ciliary epitheliumWestern blot analysisSubunit proteinsEpithelial cell lineCiliary epithelial cellsImmune responseOcular tissues