2021
Candidate Glaucoma Biomarkers: From Proteins to Metabolites, and the Pitfalls to Clinical Applications
Cueto A, Álvarez L, García M, Álvarez-Barrios A, Artime E, Cueto L, Coca-Prados M, González-Iglesias H. Candidate Glaucoma Biomarkers: From Proteins to Metabolites, and the Pitfalls to Clinical Applications. Biology 2021, 10: 763. PMID: 34439995, PMCID: PMC8389649, DOI: 10.3390/biology10080763.Peer-Reviewed Original ResearchGlaucoma biomarkersRetinal ganglion cell deathGanglion cell deathProgression of glaucomaExpression of moleculesFuture diagnostic testsHuman eye tissuesOptic nerveSystemic biomarkersHuman glaucomaIntraocular pressureDisease onsetRisk factorsIrreversible blindnessEye diseaseEarly diagnosisGlaucomaPathogenic processesEye tissuesProgressive lossDiagnostic testsNeurodegenerative diseasesBiomarker candidatesMolecular biomarkersBiomarkers
2013
Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma
González-Iglesias H, Álvarez L, García M, Escribano J, Rodríguez-Calvo PP, Fernández-Vega L, Coca-Prados M. Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma. Journal Of Proteomics 2013, 98: 65-78. PMID: 24355480, DOI: 10.1016/j.jprot.2013.12.006.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaOpen-angle glaucomaPseudoexfoliation glaucomaGlaucoma patientsInflammatory-related processesSera of patientsForms of glaucomaLarge population studiesPanel of candidatesAge-related blindnessSerum proteinsFunctional pathway analysisClinical manifestationsDietary agentsInflammatory processGlaucoma biomarkersHealthy controlsEarly diagnosisGlaucomaPatientsMajor causeSerumPopulation studiesTwo-dimensional fluorescent difference gel electrophoresisGenetic linkage studies