1994
EP2-receptor Stimulated Cyclic Amp Synthesis in Cultured Human Non-pigmented Ciliary Epithelium
Jumblatt M, Neltner A, Coca-Prados M, Paterson C. EP2-receptor Stimulated Cyclic Amp Synthesis in Cultured Human Non-pigmented Ciliary Epithelium. Experimental Eye Research 1994, 58: 563-566. PMID: 7925693, DOI: 10.1006/exer.1994.1050.Peer-Reviewed Original ResearchConceptsHuman NPE cellsReceptor subtypesProstaglandin E2 receptor subtypesCiliary epitheliumCAMP synthesisNon-pigmented epithelial cellsNPE cellsEP2 receptor subtypeCyclic AMP synthesisNon-pigmented ciliary epitheliumHuman non-pigmented ciliary epitheliumEP2 subtypeProstanoid agonistsPharmacologic characterizationSpecific receptorsHuman NonPhysiologic functionProstanoidsEpithelial cellsMethyl xanthineSubtypesAMP synthesisCyclic AMPCyclic monophosphatePGE2Pathways signaling the regulatory volume decrease of cultured nonpigmented ciliary epithelial cells.
Civan M, Coca-Prados M, Peterson-Yantorno K. Pathways signaling the regulatory volume decrease of cultured nonpigmented ciliary epithelial cells. Investigative Ophthalmology & Visual Science 1994, 35: 2876-86. PMID: 8188483.Peer-Reviewed Original ResearchConceptsRegulatory volume decreaseNonpigmented ciliary epithelial cellsProtein phosphatase inhibitor okadaic acidCiliary epithelial cellsPhosphatase inhibitor okadaic acidCultured nonpigmented ciliary epithelial cellsInhibitor okadaic acidEpithelial cellsNPE cellsHuman nonpigmented ciliary epithelial cellsCl- channelsCyclic AMPPKC inhibitor staurosporineEndogenous PKC activityOkadaic acidRegulatory responsesIntracellular cAMP concentrationCell typesPKC activatorCalcium-calmodulinPKC activityCell sortingElectronic cell sortingPathwayStaurosporine
1985
Regulation of protein phosphorylation of the intermediate-sized filament vimentin in the ciliary epithelium of the mammalian eye.
Coca-Prados M. Regulation of protein phosphorylation of the intermediate-sized filament vimentin in the ciliary epithelium of the mammalian eye. Journal Of Biological Chemistry 1985, 260: 10332-10338. PMID: 4019517, DOI: 10.1016/s0021-9258(17)39252-9.Peer-Reviewed Original ResearchConceptsBeta-adrenergic agonistsMammalian eyeAlpha-adrenergic agonist phenylephrineBeta-adrenergic antagonist timololCiliary epitheliumCultured ciliary epithelial cellsCyclic AMPCellular cyclic AMPEpithelial-derived cellsAgonist phenylephrineCiliary epithelial cellsProstaglandin E1Catecholamine hormonesMicroM forskolinSerum-free mediumCiliary processesMonoclonal antibodiesRabbit ciliary processesVimentinAdenylate cyclaseEpithelial cellsPhosphorylation of vimentinIndirect immunofluorescence microscopyIntermediate-sized filamentsAgonists
1983
Protein Phosphorylation in Cultured Human Ciliary Epithelia in Response to Activators of Adenylate Cyclase, Cyclic AMP and Analogues
Coca-Prados M, Kondo K, Sears M. Protein Phosphorylation in Cultured Human Ciliary Epithelia in Response to Activators of Adenylate Cyclase, Cyclic AMP and Analogues. 1983, 1-6. DOI: 10.1007/978-3-642-69096-9_1.Peer-Reviewed Original ResearchSpecific substrate proteinsDiverse cell systemsProtein kinase activityState of phosphorylationCyclic AMPSubstrate proteinsProtein phosphorylationEndogenous proteinsKinase activitySecond messengerHuman ciliary epitheliumPhosphorylationMembrane permeabilityProteinCell systemAdenylate cyclaseCiliary epitheliumBiologic responseMessengerActivatorAMPCyclaseResponse