DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex
Numata S, Ye T, Hyde TM, Guitart-Navarro X, Tao R, Wininger M, Colantuoni C, Weinberger DR, Kleinman JE, Lipska BK. DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex. American Journal Of Human Genetics 2012, 90: 260-272. PMID: 22305529, PMCID: PMC3276664, DOI: 10.1016/j.ajhg.2011.12.020.Peer-Reviewed Original ResearchConceptsDNA methylationPromoter regionDe novo DNA methylationNovo DNA methylationSubset of genesRole of epigeneticsPromoter DNA methylationDNA methylation signaturesGenome levelGene transcriptionGenetic varianceMethylation signaturesCpG lociHuman prefrontal cortexMethylationPrefrontal cortexUnique temporal patternGenesGenotypic variantsAdditional discoveriesBrain developmentTemporal patternsEpigeneticsTranscriptionPostnatal life