A pilot study linking reduced fronto–Striatal recruitment during reward processing to persistent bingeing following treatment for binge‐eating disorder
Balodis IM, Grilo CM, Kober H, Worhunsky PD, White MA, Stevens MC, Pearlson GD, Potenza MN. A pilot study linking reduced fronto–Striatal recruitment during reward processing to persistent bingeing following treatment for binge‐eating disorder. International Journal Of Eating Disorders 2013, 47: 376-384. PMID: 24729034, PMCID: PMC3986812, DOI: 10.1002/eat.22204.Peer-Reviewed Original ResearchConceptsBinge-eating disorderFunctional magnetic resonance imagingReward processingMonetary incentive delay taskInferior frontal gyrusIncentive delay taskBinge-eating statusMedial prefrontal cortexBrain reward circuitryNeural correlatesDelay taskSpecific brain regionsFrontal gyrusNeurobiological underpinningsOutcome phasePrefrontal cortexReward circuitryVentral striatumAnticipatory phaseBrain regionsTreatment outcomesDiminished recruitmentProcessingMagnetic resonance imagingIndividualsMonetary Reward Processing in Obese Individuals With and Without Binge Eating Disorder
Balodis IM, Kober H, Worhunsky PD, White MA, Stevens MC, Pearlson GD, Sinha R, Grilo CM, Potenza MN. Monetary Reward Processing in Obese Individuals With and Without Binge Eating Disorder. Biological Psychiatry 2013, 73: 877-886. PMID: 23462319, PMCID: PMC3686098, DOI: 10.1016/j.biopsych.2013.01.014.Peer-Reviewed Original ResearchConceptsReward/loss processingReward processingLoss processingVentromedial prefrontal cortex activityFunctional magnetic resonance imagingMonetary reward processingPrefrontal cortex activityBinge Eating DisorderVentral striatal activityNeural differencesNeural correlatesLoss taskLoss prospectsNeurobiological underpinningsCortex activityEating DisordersRegional activationVentral striatumBED groupAnticipatory phaseStriatal activityProcessingIndividualsOB groupObese individuals