2017
Altered Functional Connectivity in Sickle Cell Disease Exists at Rest and During Acute Pain Challenge
Zempsky W, Stevens M, Santanelli J, Gaynor A, Khadka S. Altered Functional Connectivity in Sickle Cell Disease Exists at Rest and During Acute Pain Challenge. The Clinical Journal Of Pain 2017, 33: 1060-1070. PMID: 28272117, DOI: 10.1097/ajp.0000000000000492.Peer-Reviewed Original ResearchConceptsSickle cell diseaseChronic pain disordersPain challengePain disordersCell diseaseSomatosensory networkBrain regionsAltered functional connectivityFunctional connectivity abnormalitiesSubcortical brain regionsLower functional integrationDefault mode networkCentral sensitizationRed blood cellsNociceptive informationPain sensitizationChronic painPain responseParietal lobe regionsPressure algometerPainful stimuliNeurodevelopmental abnormalitiesSCD controlsConnectivity abnormalitiesSalience network
2015
Language comprehension and brain function in individuals with an optimal outcome from autism
Eigsti IM, Stevens MC, Schultz RT, Barton M, Kelley E, Naigles L, Orinstein A, Troyb E, Fein DA. Language comprehension and brain function in individuals with an optimal outcome from autism. NeuroImage Clinical 2015, 10: 182-191. PMID: 26862477, PMCID: PMC4707189, DOI: 10.1016/j.nicl.2015.11.014.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderTypical developmentTD groupBrain networksSentence comprehension taskIndividuals ages 8Functional MRI scansLanguage comprehensionASD groupComprehension taskLanguage abilityLateralized regionsLanguage performanceRight homologueOO individualsSpectrum disorderBrain functioningPosterior cingulateLanguage processingAge 8Temporal regionsBrain regionsBrain functionMinority of individualsIntensive learningA Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers
Worhunsky PD, Dager AD, Meda SA, Khadka S, Stevens MC, Austad CS, Raskin SA, Tennen H, Wood RM, Fallahi CR, Potenza MN, Pearlson GD. A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers. Neuropsychopharmacology 2015, 41: 1637-1647. PMID: 26514582, PMCID: PMC4832027, DOI: 10.1038/npp.2015.332.Peer-Reviewed Original ResearchConceptsAlcohol useYoung adult drinkersYoung adultsPreliminary prospective studyAdult drinkersExcessive alcohol useAlcohol use disorderFunctional network activityProspective studyUse disordersFunctional brain networksGo/No-Go taskNeurobiological alterationsDomain scoresGreater riskDaily drinksAddictive disordersDrinkersDrinking occasionsLongitudinal studyFronto-parietal circuitryBrain networks
2013
Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition
Tolin DF, Witt ST, Stevens MC. Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition. Psychiatry Research 2013, 221: 142-148. PMID: 24389161, PMCID: PMC3946244, DOI: 10.1016/j.pscychresns.2013.11.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGo/NoGo taskFunctional magnetic resonance imagingOCD patientsHD patientsResponse inhibitionNoGo taskHealthy controlsGo/NoGo task performanceDistinct neural underpinningsRight orbitofrontal gyrusErrors of commissionNeural underpinningsOrbitofrontal activationTask performanceCorrect rejectsMagnetic resonance imagingHemodynamic activityFrontal hypoactivityNeural activityOrbitofrontal gyrusBehavioral dataHemodynamic responsePatientsPreliminary evidenceWhite matter abnormalities in adolescents with major depressive disorder
Bessette KL, Nave AM, Caprihan A, Stevens MC. White matter abnormalities in adolescents with major depressive disorder. Brain Imaging And Behavior 2013, 8: 531-541. PMID: 24242685, DOI: 10.1007/s11682-013-9274-8.Peer-Reviewed Original ResearchConceptsMajor depressive disorderWhite matter abnormalitiesDiffusion tensor imagingDepressive disorderFrontal lobeWhole brainRegional white matter abnormalitiesRight thalamic radiationOlder depressed patientsTract-based spatial statisticsCorpus callosum genuFrontal lobe tractsFractional anisotropy valuesLower FAAbnormal white matter microstructureInferior longitudinal fasciculusWhite matter connectionsWhite matter microstructureInternal capsuleExternal capsuleFA abnormalitiesDepressed patientsHealthy controlsAdolescents ages 13Posterior limb
2012
Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder
Passarotti AM, Ellis J, Wegbreit E, Stevens MC, Pavuluri MN. Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder. Brain Connectivity 2012, 2: 320-334. PMID: 23035965, PMCID: PMC3621331, DOI: 10.1089/brain.2012.0089.Peer-Reviewed Original ResearchConceptsVentrolateral prefrontal cortexPediatric bipolar disorderRight ventrolateral prefrontal cortexWorking Memory NetworkFunctional connectivityMemory taskDorsolateral PFCBrain networksRight amygdalaMemory networkEmotion processing regionsEmotion regulation regionsDifferential functional connectivityFunctional magnetic resonanceBilateral temporal regionsConnected brain networksRegulation regionRegional functional connectivityNeutral facesEmotion processingCognitive processesEmotion evaluationPrefrontal regionsProcessing regionsBipolar disorderNeural Mechanisms of Decision Making in Hoarding Disorder
Tolin DF, Stevens MC, Villavicencio AL, Norberg MM, Calhoun VD, Frost RO, Steketee G, Rauch SL, Pearlson GD. Neural Mechanisms of Decision Making in Hoarding Disorder. JAMA Psychiatry 2012, 69: 832-841. PMID: 22868937, PMCID: PMC3506167, DOI: 10.1001/archgenpsychiatry.2011.1980.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingCerebral CortexDecision MakingDiagnostic and Statistical Manual of Mental DisordersEvoked PotentialsExpressed EmotionFemaleGyrus CinguliHoarding DisorderHospitals, VoluntaryHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysObsessive BehaviorSickness Impact ProfileConceptsHealthy control subjectsObsessive-compulsive disorderAnterior cingulate cortexNeural mechanismsCingulate cortexBrain regionsNeural activityAppropriate emotional responsesFrontal brain regionsFunctional magnetic resonance imaging (fMRI) signalsPrevious neuroimaging studiesUnique diagnostic entityFunctional magnetic resonanceMagnetic resonance imaging signalsControl subjectsImpaired decisionInsula functionEmotional significanceAffective statesDepressive symptomsHoarding DisorderEmotional responsesNeuroimaging studiesPatientsPoor insightOvercoming residual interference in mental set switching: Neural correlates and developmental trajectory
Witt ST, Stevens MC. Overcoming residual interference in mental set switching: Neural correlates and developmental trajectory. NeuroImage 2012, 62: 2055-2064. PMID: 22584223, PMCID: PMC3482401, DOI: 10.1016/j.neuroimage.2012.05.007.Peer-Reviewed Original ResearchConceptsHigher taskLower taskFunctional magnetic resonance imaging studySpaced trialsSubsequent stimulus processingBrain regionsMagnetic resonance imaging studyDissociable influencesExecutive controlCognitive setResonance imaging studyNeural correlatesStimulus processingBrain systemsSwitch costsDevelopmental trajectoriesTask typeSet switchingSubcortical motor networksNew tasksInterstimulus intervalPassive decayTaskReaction timeCortical controlMultiple resting state network functional connectivity abnormalities in mild traumatic brain injury
Stevens MC, Lovejoy D, Kim J, Oakes H, Kureshi I, Witt ST. Multiple resting state network functional connectivity abnormalities in mild traumatic brain injury. Brain Imaging And Behavior 2012, 6: 293-318. PMID: 22555821, DOI: 10.1007/s11682-012-9157-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain InjuriesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeural PathwaysRestYoung AdultConceptsTraumatic brain injuryMild traumatic brain injuryMild TBI patientsFunctional connectivity abnormalitiesTBI patientsBrain injuryConnectivity abnormalitiesFunctional connectivitySevere traumatic brain injuryWhite matter microstructural damagePostconcussive symptom severityWhole-brain functional connectivityFunctional connectivity deficitsCompensatory neural processesBrain networksBrain functional connectivityHealthy control participantsVoxelwise group comparisonsIntracerebral injuryNeurobiological sequelaeConnectivity deficitsAnterior cingulateBrain regionsSymptom severityAnatomical connectivity
2011
The Effects of Stimulant Medication on Working Memory Functional Connectivity in Attention-Deficit/Hyperactivity Disorder
Wong CG, Stevens MC. The Effects of Stimulant Medication on Working Memory Functional Connectivity in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry 2011, 71: 458-466. PMID: 22209640, PMCID: PMC4120250, DOI: 10.1016/j.biopsych.2011.11.011.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderFunctional magnetic resonance imagingFunctional connectivityFMRI taskHyperactivity disorderStimulant medicationNetwork engagementMemory fMRI taskFrontoparietal brain networksBrain regionsFrontoparietal brain regionsConnectivity changesMemory reaction timeVentrolateral prefrontal cortexAdditional brain regionsGroup independent component analysisMedication-related changesFunctional connectivity analysisRegional functional connectivityFunctional connectivity changesMemory performanceRepeated-measures t-testBrain activationIndependent component analysisRetrieval phasePharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania
Pavuluri MN, Ellis JA, Wegbreit E, Passarotti AM, Stevens MC. Pharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania. Behavioural Brain Research 2011, 226: 493-503. PMID: 22004983, PMCID: PMC3253527, DOI: 10.1016/j.bbr.2011.10.003.Peer-Reviewed Original ResearchConceptsPediatric bipolar disorderAffective circuitsFunctional connectivityResponse inhibitionFMRI taskEmotional influencesAmygdala activityBehavioral inhibitionTask performanceTrait deficitAmygdala connectivityNeural operationsPediatric maniaNormative comparisonsSubgenual ACCFMRI trialAnti-epileptic medicationsMotor responseGreater engagementDifferential influenceStop signalBehavioral differencesCurrent studyDivalproex groupRisperidone group
2010
Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients
Assaf M, Jagannathan K, Calhoun VD, Miller L, Stevens MC, Sahl R, O'Boyle JG, Schultz RT, Pearlson GD. Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients. NeuroImage 2010, 53: 247-256. PMID: 20621638, PMCID: PMC3058935, DOI: 10.1016/j.neuroimage.2010.05.067.Peer-Reviewed Original ResearchBrain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach
Skudlarski P, Jagannathan K, Anderson K, Stevens MC, Calhoun VD, Skudlarska BA, Pearlson G. Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach. Biological Psychiatry 2010, 68: 61-69. PMID: 20497901, PMCID: PMC2900394, DOI: 10.1016/j.biopsych.2010.03.035.Peer-Reviewed Original ResearchConceptsBrain connectivityFunctional connectivitySchizophrenia patientsAnatomical connectivityState functional magnetic resonance imagingFunctional connectivity alterationsHealthy control subjectsClinical symptom severityGroup differencesAnatomical connectivity mapsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cingulate cortexGlobal connectivity analysisClinical symptomsWhite matter anatomyControl subjectsConnectivity alterationsCingulate cortexPatientsResonance imagingBrain regionsSymptom severityDMN componentsTask-positive network
2009
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
Meda SA, Jagannathan K, Gelernter J, Calhoun VD, Liu J, Stevens MC, Pearlson GD. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. NeuroImage 2009, 53: 1007-1015. PMID: 19944766, PMCID: PMC3968678, DOI: 10.1016/j.neuroimage.2009.11.052.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationBrain MappingBrain-Derived Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsEndophenotypesFemaleGenetic Predisposition to DiseaseGenotypeHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysPilot ProjectsPolymorphism, Single NucleotideSchizophreniaSerotonin Plasma Membrane Transport ProteinsConceptsDopamine transporterBrain functionNeurotropic factorAuditory oddball taskSchizophrenia patientsSingle nucleotide polymorphismsMultiple risk genesRisk genesOddball taskRelated brain functionsHealthy controlsSchizophrenia risk genesAbnormal activationGenomic factorsTemporal gyrusPatientsTask-relevant regionsSchizophreniaSignificant differencesAttention/Multiple single nucleotide polymorphismsGenetic profilePsychiatric neuroimagingBrainGenotype-phenotype relationshipsAge-related cognitive gains are mediated by the effects of white matter development on brain network integration
Stevens MC, Skudlarski P, Pearlson GD, Calhoun VD. Age-related cognitive gains are mediated by the effects of white matter development on brain network integration. NeuroImage 2009, 48: 738-746. PMID: 19577651, PMCID: PMC2753497, DOI: 10.1016/j.neuroimage.2009.06.065.Peer-Reviewed Original ResearchConceptsCognitive controlBrain activityWhite matter developmentDevelopmental cognitive neuroscienceExecutive cognitive abilityBrain network integrationWhite matter coherenceCognitive neuroscienceCognitive abilitiesResponse inhibitionAdolescent developmentCognitive gainsBehavioral performanceSpecific white matter regionsFunctional integrationAge-related changesFirst multimodalBehavioral controlFunctional connectivityMaturational factorsBrain regionsLocal processingNetwork integrationFunctional circuitsNeuroscienceInvestigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls
Demirci O, Stevens MC, Andreasen NC, Michael A, Liu J, White T, Pearlson GD, Clark VP, Calhoun VD. Investigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls. NeuroImage 2009, 46: 419-431. PMID: 19245841, PMCID: PMC2713821, DOI: 10.1016/j.neuroimage.2009.02.014.Peer-Reviewed Original ResearchConceptsFunctional network connectivitySternberg Item Recognition ParadigmTemporal lobe activationBrain networksBrain activation networksCerebral sitesHealthy controlsAuditory oddball taskPsychiatric disordersSchizophrenia patientsControl groupAOD taskCausal relationshipFMRI brain networksTime courseOddball taskThe developmental cognitive neuroscience of functional connectivity
Stevens MC. The developmental cognitive neuroscience of functional connectivity. Brain And Cognition 2009, 70: 1-12. PMID: 19185406, DOI: 10.1016/j.bandc.2008.12.009.Peer-Reviewed Original ResearchConceptsDevelopmental cognitive neuroscienceCognitive neuroscienceFunctional connectivityFunctional connectivity analysisFunctional integrationCognitive controlBrain functional integrationCognitive maturationCognitive abilitiesConnectivity analysis methodCognitive developmentNeural substratesDevelopmental theoristsBehavioral controlConnectivity analysisNeuroscienceBrain regionsConceptual reviewCentral conceptBiological developmentRelevant conceptsCognitionRecent findingsNeural networkAdolescenceChanges in the interaction of resting‐state neural networks from adolescence to adulthood
Stevens MC, Pearlson GD, Calhoun VD. Changes in the interaction of resting‐state neural networks from adolescence to adulthood. Human Brain Mapping 2009, 30: 2356-2366. PMID: 19172655, PMCID: PMC6788906, DOI: 10.1002/hbm.20673.Peer-Reviewed Original Research
2007
A method for functional network connectivity among spatially independent resting-state components in schizophrenia
Jafri MJ, Pearlson GD, Stevens M, Calhoun VD. A method for functional network connectivity among spatially independent resting-state components in schizophrenia. NeuroImage 2007, 39: 1666-1681. PMID: 18082428, PMCID: PMC3164840, DOI: 10.1016/j.neuroimage.2007.11.001.Peer-Reviewed Original ResearchConceptsFunctional network connectivityFunctional connectivityTime courseICA time coursesHealthy controlsMagnetic resonance imaging dataHealthy individualsPatientsBrain disordersBrain regionsState fMRI dataCortical processingSchizophreniaFunctional magnetic resonance imaging (fMRI) dataSpatial independent component analysisSignificant differencesBrain networksComponent time coursesTemporal relationshipCoherent brain regionsBrainFMRI dataCourseImaging dataSeed voxels