2013
Time course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder
Yang H, Lu LH, Wu M, Stevens M, Wegbreit E, Fitzgerald J, Levitan B, Shankman S, Pavuluri MN. Time course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder. Journal Of Affective Disorders 2013, 150: 571-577. PMID: 23517886, PMCID: PMC3745513, DOI: 10.1016/j.jad.2013.02.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBipolar DisorderBrainChildCognition DisordersEmotionsFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMalePrognosisConceptsDorsal lateral prefrontal cortexPediatric bipolar disorderVentral lateral prefrontal cortexAnterior cingulate cortexHealthy controlsBipolar disorderLateral prefrontal cortexCortical regionsPrefrontal cortexRight dorsal lateral prefrontal cortexBilateral anterior cingulate cortexVentral cortical regionsFronto-limbic circuitsGreater activationPrefrontal cortex changesPresent findingsProlonged lengthMedication algorithmSubcortical changesUnmedicated patientsFronto-striatalPharmacological interventionsPBD groupSubcortical activityCingulate cortex
2012
Examining the effect of psychopathic traits on gray matter volume in a community substance abuse sample
Cope LM, Shane MS, Segall JM, Nyalakanti PK, Stevens MC, Pearlson GD, Calhoun VD, Kiehl KA. Examining the effect of psychopathic traits on gray matter volume in a community substance abuse sample. Psychiatry Research 2012, 204: 91-100. PMID: 23217577, PMCID: PMC3536442, DOI: 10.1016/j.pscychresns.2012.10.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntisocial Personality DisorderBrainCognition DisordersFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNerve Fibers, MyelinatedNeuropsychological TestsPersonality InventoryPsychiatric Status Rating ScalesRegression AnalysisResidence CharacteristicsSubstance-Related DisordersConceptsGray matter volumeMatter volumeOrbital frontal cortexMagnetic resonance imagingRight hippocampusFrontal cortexBilateral orbital frontal cortexRight anterior cingulateGray matter reductionsGray matter increasesStructural imaging studiesLimbic regionsBrain abnormalitiesRight insulaParalimbic regionsAnterior cingulateLifetime drugSubstance abuse sampleResonance imagingImaging studiesAlcohol useExploratory regression analysisRegression analysisLimbicMatter reduction
2007
An fMRI Auditory Oddball Study of Combined-Subtype Attention Deficit Hyperactivity Disorder
Stevens MC, Pearlson GD, Kiehl KA. An fMRI Auditory Oddball Study of Combined-Subtype Attention Deficit Hyperactivity Disorder. American Journal Of Psychiatry 2007, 164: 1737-1749. PMID: 17974940, DOI: 10.1176/appi.ajp.2007.06050876.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdolescentAdolescent BehaviorAttentionAttention Deficit Disorder with HyperactivityAuditory PerceptionBrainBrain MappingCerebral CortexChildCognition DisordersDiagnostic and Statistical Manual of Mental DisordersEvoked PotentialsHemodynamicsHumansMagnetic Resonance ImagingMaleMemory DisordersOrientationOxygenPsychiatric Status Rating ScalesPsychomotor PerformanceConceptsAttention deficit hyperactivity disorderEvent-related potentialsFunctional magnetic resonance imagingDeficit hyperactivity disorderBrain regionsHyperactivity disorderHemodynamic activityThree-stimulus auditory oddball taskP3 event-related potentialEvent-related fMRI dataProcessing of targetsAbnormal hemodynamic activityWorking Memory DeficitsSlower task performanceAuditory oddball taskNovel environmental stimuliCortical brain regionsAttentional orientingOrient attentionADHD participantsCognitive processesCognitive representationsOddball studiesNeurobiological theoriesOddball stimuli
2004
The Effect of Short‐Term Estradiol Therapy on Cognitive Function in Older Men Receiving Hormonal Suppression Therapy for Prostate Cancer
Taxel P, Stevens MC, Trahiotis M, Zimmerman J, Kaplan RF. The Effect of Short‐Term Estradiol Therapy on Cognitive Function in Older Men Receiving Hormonal Suppression Therapy for Prostate Cancer. Journal Of The American Geriatrics Society 2004, 52: 269-273. PMID: 14728639, DOI: 10.1111/j.1532-5415.2004.52067.x.Peer-Reviewed Original ResearchConceptsProstate cancerOlder menCognitive functionShort-term estradiol therapyGeneral Clinical Research CenterCognitive deficitsSex hormone-binding globulinE replacement therapyHormonal suppression therapyClinical Research CenterCommunity-dwelling menSelf-reported cognitive deficitsHormone-binding globulinEffects of estrogenSymptoms of depressionSignificant differencesStandardized neurocognitive testsEstradiol therapyHypogonadal menPostmenopausal womenSuppression therapyReplacement therapyBone turnoverHormone levelsDepressive symptoms
2003
Executive–cognitive functioning in the development of antisocial personality disorder
Stevens MC, Kaplan RF, Hesselbrock VM. Executive–cognitive functioning in the development of antisocial personality disorder. Addictive Behaviors 2003, 28: 285-300. PMID: 12573679, DOI: 10.1016/s0306-4603(01)00232-5.Peer-Reviewed Original ResearchConceptsChildhood conduct disorderAntisocial personality disorderAbstraction abilityCognitive ability profilesExecutive cognitive functioningAbnormal behavioral outcomesPorteus Maze TestPersonality disorderFamily historyFunctioning abilityAntisocial samplesNeuropsychological measuresConduct problemsAbility profilesMotor planningAntisocial behaviorConduct disorderBehavioral outcomesBehavior severityMotor tasksPositive family historyYoung male adultsMaturational processesASPD subjectsAlcohol dependence
2001
Relationship of cognitive ability to the developmental course of antisocial behavior in substance-dependent patients
Stevens M, Kaplan R, Bauer L. Relationship of cognitive ability to the developmental course of antisocial behavior in substance-dependent patients. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2001, 25: 1523-1536. PMID: 11642652, DOI: 10.1016/s0278-5846(01)00210-x.Peer-Reviewed Original ResearchConceptsChildhood conduct disorderSubstance-dependent patientsPatient groupAbstinent substance dependent patientsConduct disorderNon-drug usersLiving ScaleDiagnostic criteriaPatientsControl groupCocaine dependenceSubstance dependenceDevelopmental courseAge 15Antisocial behaviorSubject groupsASPDSignificant differencesScoresAdultsDual alcoholDisordersPresent studyDisorder behaviorsAdulthood