2013
Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives
Skudlarski P, Schretlen DJ, Thaker GK, Stevens MC, Keshavan MS, Sweeney JA, Tamminga CA, Clementz BA, O’Neil K, Pearlson GD. Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives. American Journal Of Psychiatry 2013, 170: 886-898. PMID: 23771210, DOI: 10.1176/appi.ajp.2013.12111448.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnisotropyBipolar DisorderBrainDiffusion Tensor ImagingDominance, CerebralEndophenotypesGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedLeukoencephalopathiesNerve NetPhenotypePsychiatric Status Rating ScalesReference ValuesSchizophreniaSchizophrenic PsychologyStatistics as TopicConceptsPsychotic bipolar disorderBipolar disorderWhite matter integrityFractional anisotropyComparison subjectsFractional anisotropy decreasesFirst-degree relativesHealthy comparison subjectsLower white matter integrityDiffusion tensorMultiple white matter regionsLower fractional anisotropyWhite matter regionsBipolar-Schizophrenia NetworkHealthy subjectsBipolar relativesProband groupsYoung subjectsBrain regionsDisease specificityFractional anisotropy measuresUnaffected relativesMatter regionsBrain connectivitySchizophreniaIs Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study
Khadka S, Meda SA, Stevens MC, Glahn DC, Calhoun VD, Sweeney JA, Tamminga CA, Keshavan MS, O’Neil K, Schretlen D, Pearlson GD. Is Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study. Biological Psychiatry 2013, 74: 458-466. PMID: 23746539, PMCID: PMC3752322, DOI: 10.1016/j.biopsych.2013.04.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderBrainBrain MappingEndophenotypesFemaleHumansMagnetic Resonance ImagingMaleNerve NetRestSchizophreniaConceptsPsychotic bipolar probandsNegative Syndrome Scale (PANSS) negative scoresState functional magnetic resonance imaging studyFunctional connectivityState functional magnetic resonanceBipolar disorder shareBrain connectivity abnormalitiesPosterior default mode networkSchizophrenia probandsMagnetic resonance imaging studyRespective first-degree relativesAberrant functional connectivityBipolar probandsFirst-degree relativesGroup differencesPsychosis endophenotypesNegative Syndrome ScaleResonance imaging studyFunctional magnetic resonance imaging studyDefault mode networkFunctional magnetic resonanceFunctional connectivity measures
2009
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
Meda SA, Jagannathan K, Gelernter J, Calhoun VD, Liu J, Stevens MC, Pearlson GD. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. NeuroImage 2009, 53: 1007-1015. PMID: 19944766, PMCID: PMC3968678, DOI: 10.1016/j.neuroimage.2009.11.052.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationBrain MappingBrain-Derived Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsEndophenotypesFemaleGenetic Predisposition to DiseaseGenotypeHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysPilot ProjectsPolymorphism, Single NucleotideSchizophreniaSerotonin Plasma Membrane Transport ProteinsConceptsDopamine transporterBrain functionNeurotropic factorAuditory oddball taskSchizophrenia patientsSingle nucleotide polymorphismsMultiple risk genesRisk genesOddball taskRelated brain functionsHealthy controlsSchizophrenia risk genesAbnormal activationGenomic factorsTemporal gyrusPatientsTask-relevant regionsSchizophreniaSignificant differencesAttention/Multiple single nucleotide polymorphismsGenetic profilePsychiatric neuroimagingBrainGenotype-phenotype relationships