2015
Neuroimaging data sharing on the neuroinformatics database platform
Book GA, Stevens MC, Assaf M, Glahn DC, Pearlson GD. Neuroimaging data sharing on the neuroinformatics database platform. NeuroImage 2015, 124: 1089-1092. PMID: 25888923, PMCID: PMC4608854, DOI: 10.1016/j.neuroimage.2015.04.022.Peer-Reviewed Original Research
2013
Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study
Narayanan B, O’Neil K, Berwise C, Stevens MC, Calhoun VD, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS, Pearlson GD. Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study. Biological Psychiatry 2013, 76: 456-465. PMID: 24439302, PMCID: PMC5045030, DOI: 10.1016/j.biopsych.2013.12.008.Peer-Reviewed Original ResearchConceptsFirst-degree relativesSlow beta activityFast alpha activitySZ probandsAlpha activityHealthy control subjectsBeta activityRelative risk estimatesFrontal delta activityEEG spectral activityModerate relative riskPsychotic bipolar patientsLow-frequency activityPsychotic bipolar probandsGroup independent component analysisControl subjectsRelative riskPost-hoc pair-wise comparisonsBipolar patientsGenetic predispositionIntermediate Phenotypes (B-SNIP) studyOscillatory abnormalitiesAnalysis of covarianceUnique endophenotypesBipolar disorderProlonged hemodynamic response during incidental facial emotion processing in inter-episode bipolar I disorder
Rosenfeld ES, Pearlson GD, Sweeney JA, Tamminga CA, Keshavan MS, Nonterah C, Stevens MC. Prolonged hemodynamic response during incidental facial emotion processing in inter-episode bipolar I disorder. Brain Imaging And Behavior 2013, 8: 73-86. PMID: 23975275, PMCID: PMC3944373, DOI: 10.1007/s11682-013-9246-z.Peer-Reviewed Original ResearchConceptsFMRI studyDorsolateral prefrontal cortex responsesAutomatic emotion regulationAffectively salient stimuliFacial emotion processingGender discrimination taskBrain regionsRemitted bipolar disorderPrefrontal cortex responsesResidual mood symptomsPrefrontal cortex regionsDiagnostic group differencesVentromedial prefrontal cortex regionsCortex brain regionsAngry expressionsEmotion regulationEmotion processingEmotional processingBrain activationTask performanceHemodynamic responseEmotional reactionsBipolar disorderBipolar IPrefrontal cortexDiffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives
Skudlarski P, Schretlen DJ, Thaker GK, Stevens MC, Keshavan MS, Sweeney JA, Tamminga CA, Clementz BA, O’Neil K, Pearlson GD. Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives. American Journal Of Psychiatry 2013, 170: 886-898. PMID: 23771210, DOI: 10.1176/appi.ajp.2013.12111448.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnisotropyBipolar DisorderBrainDiffusion Tensor ImagingDominance, CerebralEndophenotypesGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedLeukoencephalopathiesNerve NetPhenotypePsychiatric Status Rating ScalesReference ValuesSchizophreniaSchizophrenic PsychologyStatistics as TopicConceptsPsychotic bipolar disorderBipolar disorderWhite matter integrityFractional anisotropyComparison subjectsFractional anisotropy decreasesFirst-degree relativesHealthy comparison subjectsLower white matter integrityDiffusion tensorMultiple white matter regionsLower fractional anisotropyWhite matter regionsBipolar-Schizophrenia NetworkHealthy subjectsBipolar relativesProband groupsYoung subjectsBrain regionsDisease specificityFractional anisotropy measuresUnaffected relativesMatter regionsBrain connectivitySchizophreniaIs Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study
Khadka S, Meda SA, Stevens MC, Glahn DC, Calhoun VD, Sweeney JA, Tamminga CA, Keshavan MS, O’Neil K, Schretlen D, Pearlson GD. Is Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study. Biological Psychiatry 2013, 74: 458-466. PMID: 23746539, PMCID: PMC3752322, DOI: 10.1016/j.biopsych.2013.04.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderBrainBrain MappingEndophenotypesFemaleHumansMagnetic Resonance ImagingMaleNerve NetRestSchizophreniaConceptsPsychotic bipolar probandsNegative Syndrome Scale (PANSS) negative scoresState functional magnetic resonance imaging studyFunctional connectivityState functional magnetic resonanceBipolar disorder shareBrain connectivity abnormalitiesPosterior default mode networkSchizophrenia probandsMagnetic resonance imaging studyRespective first-degree relativesAberrant functional connectivityBipolar probandsFirst-degree relativesGroup differencesPsychosis endophenotypesNegative Syndrome ScaleResonance imaging studyFunctional magnetic resonance imaging studyDefault mode networkFunctional magnetic resonanceFunctional connectivity measuresTime course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder
Yang H, Lu LH, Wu M, Stevens M, Wegbreit E, Fitzgerald J, Levitan B, Shankman S, Pavuluri MN. Time course of recovery showing initial prefrontal cortex changes at 16 weeks, extending to subcortical changes by 3 years in pediatric bipolar disorder. Journal Of Affective Disorders 2013, 150: 571-577. PMID: 23517886, PMCID: PMC3745513, DOI: 10.1016/j.jad.2013.02.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBipolar DisorderBrainChildCognition DisordersEmotionsFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMalePrognosisConceptsDorsal lateral prefrontal cortexPediatric bipolar disorderVentral lateral prefrontal cortexAnterior cingulate cortexHealthy controlsBipolar disorderLateral prefrontal cortexCortical regionsPrefrontal cortexRight dorsal lateral prefrontal cortexBilateral anterior cingulate cortexVentral cortical regionsFronto-limbic circuitsGreater activationPrefrontal cortex changesPresent findingsProlonged lengthMedication algorithmSubcortical changesUnmedicated patientsFronto-striatalPharmacological interventionsPBD groupSubcortical activityCingulate cortex
2012
RETRACTED: Where, when, how high, and how long? The hemodynamics of emotional response in psychotropic-naïve patients with adolescent bipolar disorder.
Wegbreit E, Passarotti AM, Ellis JA, Wu M, Witowski N, Fitzgerald JM, Stevens MC, Pavuluri MN. RETRACTED: Where, when, how high, and how long? The hemodynamics of emotional response in psychotropic-naïve patients with adolescent bipolar disorder. Journal Of Affective Disorders 2012, 147: 304-311. PMID: 23261134, PMCID: PMC3606663, DOI: 10.1016/j.jad.2012.11.025.Peer-Reviewed Original ResearchConceptsFearful facesPrefrontal cortexNeutral facesRight dorsolateral prefrontal cortexEmotion-attention interactionsEnhanced neural processingVentrolateral prefrontal cortexEmotional processing regionsDorsolateral prefrontal cortexAdolescent bipolar disorderProbe taskEmotional facesPrefrontal activityNeural processingSpaced stimuliABD groupEmotional responsesProcessing regionsBilateral amygdalaDisorder exhibitMixed mood statesMood statesHealthy controlsNeural activityBipolar disorder exhibitReduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder
Passarotti AM, Ellis J, Wegbreit E, Stevens MC, Pavuluri MN. Reduced Functional Connectivity of Prefrontal Regions and Amygdala Within Affect and Working Memory Networks in Pediatric Bipolar Disorder. Brain Connectivity 2012, 2: 320-334. PMID: 23035965, PMCID: PMC3621331, DOI: 10.1089/brain.2012.0089.Peer-Reviewed Original ResearchConceptsVentrolateral prefrontal cortexPediatric bipolar disorderRight ventrolateral prefrontal cortexWorking Memory NetworkFunctional connectivityMemory taskDorsolateral PFCBrain networksRight amygdalaMemory networkEmotion processing regionsEmotion regulation regionsDifferential functional connectivityFunctional magnetic resonanceBilateral temporal regionsConnected brain networksRegulation regionRegional functional connectivityNeutral facesEmotion processingCognitive processesEmotion evaluationPrefrontal regionsProcessing regionsBipolar disorderNeural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder
Ethridge LE, Hamm JP, Shapiro JR, Summerfelt AT, Keedy SK, Stevens MC, Pearlson G, Tamminga CA, Boutros NN, Sweeney JA, Keshavan MS, Thaker G, Clementz BA. Neural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder. Biological Psychiatry 2012, 72: 766-774. PMID: 22572033, PMCID: PMC3465513, DOI: 10.1016/j.biopsych.2012.03.034.Peer-Reviewed Original ResearchConceptsAuditory oddball taskBipolar disorderNeural responsesBest differentiated groupsSingular time pointsDifferent psychotic disordersAuditory processing abnormalitiesOddball taskPsychotic bipolar disorderP300 event-related potentialNonpsychotic patientsHealthy subjectsPsychotic disordersPsychosis groupAuditory oddball responsePsychotic groupSchizophreniaFrequent combinationTime pointsBrain activationNeural activationBeta activityGroup differencesBrain responsesDisordersDifferences in Resting-State Functional Magnetic Resonance Imaging Functional Network Connectivity Between Schizophrenia and Psychotic Bipolar Probands and Their Unaffected First-Degree Relatives
Meda SA, Gill A, Stevens MC, Lorenzoni RP, Glahn DC, Calhoun VD, Sweeney JA, Tamminga CA, Keshavan MS, Thaker G, Pearlson GD. Differences in Resting-State Functional Magnetic Resonance Imaging Functional Network Connectivity Between Schizophrenia and Psychotic Bipolar Probands and Their Unaffected First-Degree Relatives. Biological Psychiatry 2012, 71: 881-889. PMID: 22401986, PMCID: PMC3968680, DOI: 10.1016/j.biopsych.2012.01.025.Peer-Reviewed Original ResearchConceptsUnaffected first-degree relativesFirst-degree relativesPsychotic bipolar probandsBipolar probandsNegative Syndrome Scale (PANSS) scoresBipolar disorder shareFunctional brain dysconnectivityIndividual resting-state networksFunctional network connectivity analysisPANSS negative scoresResting-state networksFunctional network connectivityFunctional magnetic resonanceControl subjectsBrain dysconnectivityDisorder sharesHealthy subjectsBipolar relativesParalimbic circuitsScale scoreConnectivity differencesClinical relationshipSchizophreniaAbnormal pairsProbands
2011
Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis
Hamm JP, Ethridge LE, Shapiro JR, Stevens MC, Boutros NN, Summerfelt AT, Keshavan MS, Sweeney JA, Pearlson G, Tamminga CA, Thaker G, Clementz BA. Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis. Psychophysiology 2011, 49: 522-530. PMID: 22176721, PMCID: PMC3309114, DOI: 10.1111/j.1469-8986.2011.01327.x.Peer-Reviewed Original ResearchAmygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder
Wegbreit E, Ellis JA, Nandam A, Fitzgerald JM, Passarotti AM, Pavuluri MN, Stevens MC. Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder. Brain Connectivity 2011, 1: 411-422. PMID: 22432455, PMCID: PMC3604767, DOI: 10.1089/brain.2011.0035.Peer-Reviewed Original ResearchPharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania
Pavuluri MN, Ellis JA, Wegbreit E, Passarotti AM, Stevens MC. Pharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania. Behavioural Brain Research 2011, 226: 493-503. PMID: 22004983, PMCID: PMC3253527, DOI: 10.1016/j.bbr.2011.10.003.Peer-Reviewed Original ResearchConceptsPediatric bipolar disorderAffective circuitsFunctional connectivityResponse inhibitionFMRI taskEmotional influencesAmygdala activityBehavioral inhibitionTask performanceTrait deficitAmygdala connectivityNeural operationsPediatric maniaNormative comparisonsSubgenual ACCFMRI trialAnti-epileptic medicationsMotor responseGreater engagementDifferential influenceStop signalBehavioral differencesCurrent studyDivalproex groupRisperidone group