2012
A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort
Meda SA, Narayanan B, Liu J, Perrone-Bizzozero NI, Stevens MC, Calhoun VD, Glahn DC, Shen L, Risacher SL, Saykin AJ, Pearlson GD. A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort. NeuroImage 2012, 60: 1608-1621. PMID: 22245343, PMCID: PMC3312985, DOI: 10.1016/j.neuroimage.2011.12.076.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseBrainCanadaCohort StudiesData Interpretation, StatisticalFemaleGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingMaleMultivariate AnalysisPolymorphism, Single NucleotidePrevalencePrincipal Component AnalysisReproducibility of ResultsSensitivity and SpecificityUnited StatesConceptsLate-onset Alzheimer's diseaseMagnetic resonance imagingAlzheimer's diseaseOnset Alzheimer's diseaseAlzheimer's Disease Neuroimaging Initiative (ADNI) cohortElderly healthy controlsAmnestic mild cognitive impairmentDifferent brain regionsMild cognitive impairmentStructural MRI scansHealthy controlsCardiovascular diseaseInitiative cohortMRI scansPathologic processesCognitive impairmentResonance imagingBrain regionsSingle nucleotide polymorphism (SNP) variantsCaucasian adultsSubject cohortDiseasePhysiologic pathwaysCohortPolymorphism variants
2004
The Effect of Short‐Term Estradiol Therapy on Cognitive Function in Older Men Receiving Hormonal Suppression Therapy for Prostate Cancer
Taxel P, Stevens MC, Trahiotis M, Zimmerman J, Kaplan RF. The Effect of Short‐Term Estradiol Therapy on Cognitive Function in Older Men Receiving Hormonal Suppression Therapy for Prostate Cancer. Journal Of The American Geriatrics Society 2004, 52: 269-273. PMID: 14728639, DOI: 10.1111/j.1532-5415.2004.52067.x.Peer-Reviewed Original ResearchConceptsProstate cancerOlder menCognitive functionShort-term estradiol therapyGeneral Clinical Research CenterCognitive deficitsSex hormone-binding globulinE replacement therapyHormonal suppression therapyClinical Research CenterCommunity-dwelling menSelf-reported cognitive deficitsHormone-binding globulinEffects of estrogenSymptoms of depressionSignificant differencesStandardized neurocognitive testsEstradiol therapyHypogonadal menPostmenopausal womenSuppression therapyReplacement therapyBone turnoverHormone levelsDepressive symptoms