2013
Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives
Skudlarski P, Schretlen DJ, Thaker GK, Stevens MC, Keshavan MS, Sweeney JA, Tamminga CA, Clementz BA, O’Neil K, Pearlson GD. Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives. American Journal Of Psychiatry 2013, 170: 886-898. PMID: 23771210, DOI: 10.1176/appi.ajp.2013.12111448.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnisotropyBipolar DisorderBrainDiffusion Tensor ImagingDominance, CerebralEndophenotypesGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedLeukoencephalopathiesNerve NetPhenotypePsychiatric Status Rating ScalesReference ValuesSchizophreniaSchizophrenic PsychologyStatistics as TopicConceptsPsychotic bipolar disorderBipolar disorderWhite matter integrityFractional anisotropyComparison subjectsFractional anisotropy decreasesFirst-degree relativesHealthy comparison subjectsLower white matter integrityDiffusion tensorMultiple white matter regionsLower fractional anisotropyWhite matter regionsBipolar-Schizophrenia NetworkHealthy subjectsBipolar relativesProband groupsYoung subjectsBrain regionsDisease specificityFractional anisotropy measuresUnaffected relativesMatter regionsBrain connectivitySchizophrenia
2012
Neural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder
Ethridge LE, Hamm JP, Shapiro JR, Summerfelt AT, Keedy SK, Stevens MC, Pearlson G, Tamminga CA, Boutros NN, Sweeney JA, Keshavan MS, Thaker G, Clementz BA. Neural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder. Biological Psychiatry 2012, 72: 766-774. PMID: 22572033, PMCID: PMC3465513, DOI: 10.1016/j.biopsych.2012.03.034.Peer-Reviewed Original ResearchConceptsAuditory oddball taskBipolar disorderNeural responsesBest differentiated groupsSingular time pointsDifferent psychotic disordersAuditory processing abnormalitiesOddball taskPsychotic bipolar disorderP300 event-related potentialNonpsychotic patientsHealthy subjectsPsychotic disordersPsychosis groupAuditory oddball responsePsychotic groupSchizophreniaFrequent combinationTime pointsBrain activationNeural activationBeta activityGroup differencesBrain responsesDisorders
2011
Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis
Hamm JP, Ethridge LE, Shapiro JR, Stevens MC, Boutros NN, Summerfelt AT, Keshavan MS, Sweeney JA, Pearlson G, Tamminga CA, Thaker G, Clementz BA. Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis. Psychophysiology 2011, 49: 522-530. PMID: 22176721, PMCID: PMC3309114, DOI: 10.1111/j.1469-8986.2011.01327.x.Peer-Reviewed Original Research
2009
Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis
Meda SA, Stevens MC, Folley BS, Calhoun VD, Pearlson GD. Evidence for Anomalous Network Connectivity during Working Memory Encoding in Schizophrenia: An ICA Based Analysis. PLOS ONE 2009, 4: e7911. PMID: 19936244, PMCID: PMC2775682, DOI: 10.1371/journal.pone.0007911.Peer-Reviewed Original ResearchConceptsTask accuracyFunctional connectivityPrefrontal cortexNetwork engagementLeft fronto-parietal networkRight dorsolateral prefrontal cortexMemory fMRI paradigmWorking Memory EncodingFronto-parietal networkVentrolateral prefrontal cortexNumerous neuroimaging studiesDorsolateral prefrontal cortexIndependent component analysisAbnormal regional brain activityDefault mode networkBrain network integrationDysfunctional brain regionsPrevious schizophrenia studiesRegional brain activityHippocampus/parahippocampusMemory encodingFMRI taskMemory cognitionMemory performanceFMRI paradigm