Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Carroll KM, Potenza MN. Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery. Neuropsychopharmacology 2016, 41: 2112-2121. PMID: 26792441, PMCID: PMC4908642, DOI: 10.1038/npp.2016.11.Peer-Reviewed Original ResearchConceptsLeft inferior frontal gyrus activityCD participantsNegative urine screensReward/loss processingHealthy control participantsReward processingMeaningful outcome indicatorsDopamine-innervated regionsFunctional magnetic resonanceInferior frontal gyrus activityCD outpatientsTest-retest resultsPrefrontal cortex activityVentromedial prefrontal cortex activityUrine screensNeurofunctional alterationsVentral striatal activityCD groupNeurofunctional changesLong-term recoveryDrug useNeurobiological changesCocaine abstinenceCocaine dependenceStriatal activity