2010
Genetic Associations of Brain Structural Networks in Schizophrenia: A Preliminary Study
Jagannathan K, Calhoun VD, Gelernter J, Stevens MC, Liu J, Bolognani F, Windemuth A, Ruaño G, Assaf M, Pearlson GD. Genetic Associations of Brain Structural Networks in Schizophrenia: A Preliminary Study. Biological Psychiatry 2010, 68: 657-666. PMID: 20691427, PMCID: PMC2990476, DOI: 10.1016/j.biopsych.2010.06.002.Peer-Reviewed Original ResearchConceptsSpecific structural brain abnormalitiesMagnetic resonance imaging (MRI) scansSmall sample sizeHealthy control subjectsStructural brain abnormalitiesStructural magnetic resonance imaging (MRI) scansGray matter deficitsResonance imaging scansCortical gray matterNormal central nervous system developmentRisk genesCentral nervous system developmentBrain structural networksControl subjectsImaging scansBrain abnormalitiesNervous system developmentIllness markersSchizophrenia pathophysiologySchizophrenia risk genesGenetic componentTemporal lobeBrain areasEuropean-American subjectsSchizophrenia patientsBrain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach
Skudlarski P, Jagannathan K, Anderson K, Stevens MC, Calhoun VD, Skudlarska BA, Pearlson G. Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach. Biological Psychiatry 2010, 68: 61-69. PMID: 20497901, PMCID: PMC2900394, DOI: 10.1016/j.biopsych.2010.03.035.Peer-Reviewed Original ResearchConceptsBrain connectivityFunctional connectivitySchizophrenia patientsAnatomical connectivityState functional magnetic resonance imagingFunctional connectivity alterationsHealthy control subjectsClinical symptom severityGroup differencesAnatomical connectivity mapsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cingulate cortexGlobal connectivity analysisClinical symptomsWhite matter anatomyControl subjectsConnectivity alterationsCingulate cortexPatientsResonance imagingBrain regionsSymptom severityDMN componentsTask-positive network
2009
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
Meda SA, Jagannathan K, Gelernter J, Calhoun VD, Liu J, Stevens MC, Pearlson GD. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. NeuroImage 2009, 53: 1007-1015. PMID: 19944766, PMCID: PMC3968678, DOI: 10.1016/j.neuroimage.2009.11.052.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationBrain MappingBrain-Derived Neurotrophic FactorDopamine Plasma Membrane Transport ProteinsEndophenotypesFemaleGenetic Predisposition to DiseaseGenotypeHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleNeural PathwaysPilot ProjectsPolymorphism, Single NucleotideSchizophreniaSerotonin Plasma Membrane Transport ProteinsConceptsDopamine transporterBrain functionNeurotropic factorAuditory oddball taskSchizophrenia patientsSingle nucleotide polymorphismsMultiple risk genesRisk genesOddball taskRelated brain functionsHealthy controlsSchizophrenia risk genesAbnormal activationGenomic factorsTemporal gyrusPatientsTask-relevant regionsSchizophreniaSignificant differencesAttention/Multiple single nucleotide polymorphismsGenetic profilePsychiatric neuroimagingBrainGenotype-phenotype relationshipsInvestigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls
Demirci O, Stevens MC, Andreasen NC, Michael A, Liu J, White T, Pearlson GD, Clark VP, Calhoun VD. Investigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls. NeuroImage 2009, 46: 419-431. PMID: 19245841, PMCID: PMC2713821, DOI: 10.1016/j.neuroimage.2009.02.014.Peer-Reviewed Original ResearchConceptsFunctional network connectivitySternberg Item Recognition ParadigmTemporal lobe activationBrain networksBrain activation networksCerebral sitesHealthy controlsAuditory oddball taskPsychiatric disordersSchizophrenia patientsControl groupAOD taskCausal relationshipFMRI brain networksTime courseOddball task
2005
Abnormal hemodynamics in schizophrenia during an auditory oddball task
Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry 2005, 57: 1029-1040. PMID: 15860344, PMCID: PMC2771438, DOI: 10.1016/j.biopsych.2005.01.035.Peer-Reviewed Original ResearchConceptsAuditory oddball taskHealthy participantsOddball taskThree-stimulus auditory oddball taskDiffuse brain abnormalitiesHealthy control subjectsNovelty processingWidespread pathologic processCerebral areasControl subjectsBrain abnormalitiesMagnetic resonance imaging dataAbnormal hemodynamicsPathologic processesSchizophrenia patientsParietal cortexCognitive functionHeterogeneous disorderCerebellar circuitsSchizophreniaAbnormalitiesSignificant activationSubcortical systemsFunctional magnetic resonance imaging (fMRI) dataPatients