2016
Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Carroll KM, Potenza MN. Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery. Neuropsychopharmacology 2016, 41: 2112-2121. PMID: 26792441, PMCID: PMC4908642, DOI: 10.1038/npp.2016.11.Peer-Reviewed Original ResearchConceptsLeft inferior frontal gyrus activityCD participantsNegative urine screensReward/loss processingHealthy control participantsReward processingMeaningful outcome indicatorsDopamine-innervated regionsFunctional magnetic resonanceInferior frontal gyrus activityCD outpatientsTest-retest resultsPrefrontal cortex activityVentromedial prefrontal cortex activityUrine screensNeurofunctional alterationsVentral striatal activityCD groupNeurofunctional changesLong-term recoveryDrug useNeurobiological changesCocaine abstinenceCocaine dependenceStriatal activity
2013
Monetary Reward Processing in Obese Individuals With and Without Binge Eating Disorder
Balodis IM, Kober H, Worhunsky PD, White MA, Stevens MC, Pearlson GD, Sinha R, Grilo CM, Potenza MN. Monetary Reward Processing in Obese Individuals With and Without Binge Eating Disorder. Biological Psychiatry 2013, 73: 877-886. PMID: 23462319, PMCID: PMC3686098, DOI: 10.1016/j.biopsych.2013.01.014.Peer-Reviewed Original ResearchConceptsReward/loss processingReward processingLoss processingVentromedial prefrontal cortex activityFunctional magnetic resonance imagingMonetary reward processingPrefrontal cortex activityBinge Eating DisorderVentral striatal activityNeural differencesNeural correlatesLoss taskLoss prospectsNeurobiological underpinningsCortex activityEating DisordersRegional activationVentral striatumBED groupAnticipatory phaseStriatal activityProcessingIndividualsOB groupObese individuals
2010
Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task
Witt ST, Lovejoy DW, Pearlson GD, Stevens MC. Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task. Brain Imaging And Behavior 2010, 4: 232-247. PMID: 20703959, DOI: 10.1007/s11682-010-9102-3.Peer-Reviewed Original ResearchConceptsMild TBI patientsMild traumatic brain injuryTraumatic brain injuryBrain activityRight dorsolateral prefrontal cortexActive information maintenanceCompensatory brain activityDefault mode network dysfunctionPrefrontal cortex activityAuditory oddball taskDorsolateral prefrontal cortexTBI patientsPersistent cognitive deficitsBrain injurySimilar topographical patternEffortful formsExecutive tasksExecutive abilitiesOddball taskTask performanceMental effortNovel stimuliStimulus detectionCortex activityPrefrontal cortex