Neural Mechanisms of Decision Making in Hoarding Disorder
Tolin DF, Stevens MC, Villavicencio AL, Norberg MM, Calhoun VD, Frost RO, Steketee G, Rauch SL, Pearlson GD. Neural Mechanisms of Decision Making in Hoarding Disorder. JAMA Psychiatry 2012, 69: 832-841. PMID: 22868937, PMCID: PMC3506167, DOI: 10.1001/archgenpsychiatry.2011.1980.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingCerebral CortexDecision MakingDiagnostic and Statistical Manual of Mental DisordersEvoked PotentialsExpressed EmotionFemaleGyrus CinguliHoarding DisorderHospitals, VoluntaryHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysObsessive BehaviorSickness Impact ProfileConceptsHealthy control subjectsObsessive-compulsive disorderAnterior cingulate cortexNeural mechanismsCingulate cortexBrain regionsNeural activityAppropriate emotional responsesFrontal brain regionsFunctional magnetic resonance imaging (fMRI) signalsPrevious neuroimaging studiesUnique diagnostic entityFunctional magnetic resonanceMagnetic resonance imaging signalsControl subjectsImpaired decisionInsula functionEmotional significanceAffective statesDepressive symptomsHoarding DisorderEmotional responsesNeuroimaging studiesPatientsPoor insight