Abnormal hemodynamics in schizophrenia during an auditory oddball task
Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry 2005, 57: 1029-1040. PMID: 15860344, PMCID: PMC2771438, DOI: 10.1016/j.biopsych.2005.01.035.Peer-Reviewed Original ResearchConceptsAuditory oddball taskHealthy participantsOddball taskThree-stimulus auditory oddball taskDiffuse brain abnormalitiesHealthy control subjectsNovelty processingWidespread pathologic processCerebral areasControl subjectsBrain abnormalitiesMagnetic resonance imaging dataAbnormal hemodynamicsPathologic processesSchizophrenia patientsParietal cortexCognitive functionHeterogeneous disorderCerebellar circuitsSchizophreniaAbnormalitiesSignificant activationSubcortical systemsFunctional magnetic resonance imaging (fMRI) dataPatientsHemispheric differences in hemodynamics elicited by auditory oddball stimuli
Stevens MC, Calhoun VD, Kiehl KA. Hemispheric differences in hemodynamics elicited by auditory oddball stimuli. NeuroImage 2005, 26: 782-792. PMID: 15955488, PMCID: PMC2759643, DOI: 10.1016/j.neuroimage.2005.02.044.Peer-Reviewed Original ResearchConceptsNovel stimuliInfrequent targetsRight hemisphereHemispheric differencesGreater right hemisphere activationTask-relevant target stimuliAuditory oddball stimuliEvent-related fMRIParietal lobe activityRight hemisphere activationFrequent standard stimuliTask-irrelevant novel stimuliPrevious neuroimaging studiesHealthy adult participantsAttentional processesNovelty processingSalient stimuliTarget stimuliOddball stimuliOddball taskNeuroimaging studiesStandard stimuliInfrequent novelLeft hemisphereHemodynamic activityAn adaptive reflexive processing model of neurocognitive function: supporting evidence from a large scale (n = 100) fMRI study of an auditory oddball task
Kiehl KA, Stevens MC, Laurens KR, Pearlson G, Calhoun VD, Liddle PF. An adaptive reflexive processing model of neurocognitive function: supporting evidence from a large scale (n = 100) fMRI study of an auditory oddball task. NeuroImage 2005, 25: 899-915. PMID: 15808990, DOI: 10.1016/j.neuroimage.2004.12.035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsArousalAttentionBrainBrain MappingDominance, CerebralEvent-Related Potentials, P300FemaleHemodynamicsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNerve NetOxygenPitch DiscriminationReaction TimeReflexSex FactorsStatistics as TopicConceptsTask performanceNovel stimuliTask-relevant target stimuliProcessing of salientBrain regionsSuccessful task performanceAuditory oddball taskFunctional MRI studyNovelty processingReflexive processingSalient stimuliTarget stimuliOddball taskFMRI studyRandom effects statistical modelSubcortical systemsProcessing modelEffect of genderNeurocognitive functionInter-subject reliabilityEffects statistical modelStimuliSignificant activationFixed-effects analysisTarget detection