Pharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania
Pavuluri MN, Ellis JA, Wegbreit E, Passarotti AM, Stevens MC. Pharmacotherapy impacts functional connectivity among affective circuits during response inhibition in pediatric mania. Behavioural Brain Research 2011, 226: 493-503. PMID: 22004983, PMCID: PMC3253527, DOI: 10.1016/j.bbr.2011.10.003.Peer-Reviewed Original ResearchConceptsPediatric bipolar disorderAffective circuitsFunctional connectivityResponse inhibitionFMRI taskEmotional influencesAmygdala activityBehavioral inhibitionTask performanceTrait deficitAmygdala connectivityNeural operationsPediatric maniaNormative comparisonsSubgenual ACCFMRI trialAnti-epileptic medicationsMotor responseGreater engagementDifferential influenceStop signalBehavioral differencesCurrent studyDivalproex groupRisperidone group