Neural Mechanisms of Decision Making in Hoarding Disorder
Tolin DF, Stevens MC, Villavicencio AL, Norberg MM, Calhoun VD, Frost RO, Steketee G, Rauch SL, Pearlson GD. Neural Mechanisms of Decision Making in Hoarding Disorder. JAMA Psychiatry 2012, 69: 832-841. PMID: 22868937, PMCID: PMC3506167, DOI: 10.1001/archgenpsychiatry.2011.1980.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain MappingCerebral CortexDecision MakingDiagnostic and Statistical Manual of Mental DisordersEvoked PotentialsExpressed EmotionFemaleGyrus CinguliHoarding DisorderHospitals, VoluntaryHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysObsessive BehaviorSickness Impact ProfileConceptsHealthy control subjectsObsessive-compulsive disorderAnterior cingulate cortexNeural mechanismsCingulate cortexBrain regionsNeural activityAppropriate emotional responsesFrontal brain regionsFunctional magnetic resonance imaging (fMRI) signalsPrevious neuroimaging studiesUnique diagnostic entityFunctional magnetic resonanceMagnetic resonance imaging signalsControl subjectsImpaired decisionInsula functionEmotional significanceAffective statesDepressive symptomsHoarding DisorderEmotional responsesNeuroimaging studiesPatientsPoor insightNeural mechanisms of cognitive behavioral therapy response in Hoarding Disorder: A pilot study
Tolin D, Stevens M, Nave A, Villavicencio A, Morrison S. Neural mechanisms of cognitive behavioral therapy response in Hoarding Disorder: A pilot study. Journal Of Obsessive-Compulsive And Related Disorders 2012, 1: 180-188. DOI: 10.1016/j.jocrd.2012.04.001.Peer-Reviewed Original ResearchCognitive behavioral therapyMedial frontal gyrusFrontal gyrusHemodynamic activityManualized group cognitive behavioral therapyCognitive behavioral therapy responsePosterior cingulateFunctional magnetic resonance imaging (fMRI) taskGroup cognitive behavioral therapyRight superior temporal gyrusDecision-making taskInsula/putamenRight posterior hippocampusSuperior temporal gyrusHealthy control participantsParietal lobe regionsHippocampus/parahippocampusNeural functionHoarding DisorderNeural mechanismsBehavioral therapyTemporal gyrusPosterior hippocampusHC participantsLobe regions