2021
Relating neural processing of reward and loss prospect to risky decision-making in individuals with and without gambling disorder
Balodis I, Linnet J, Arshad F, Worhunsky P, Stevens M, Pearlson G, Potenza M. Relating neural processing of reward and loss prospect to risky decision-making in individuals with and without gambling disorder. 2021, 97-113. DOI: 10.4324/9781003140450-7.ChaptersMonetary incentive delay taskIowa Gambling TaskIncentive delay taskGambling disorderAnticipatory processingIGT scoresIGT performanceDelay taskIowa Gambling Task performanceProspect of rewardDecision-making impairmentsGambling Task performanceVentromedial prefrontal cortexDecision-making taskWhole-brain correlationFronto-striatal activityHC groupVentral striatum/Healthy control participantsTotal IGT scoreAnterior cingulate regionsGambling TaskNeural processesNeural processingTask performance
2013
A pilot study linking reduced fronto–Striatal recruitment during reward processing to persistent bingeing following treatment for binge‐eating disorder
Balodis IM, Grilo CM, Kober H, Worhunsky PD, White MA, Stevens MC, Pearlson GD, Potenza MN. A pilot study linking reduced fronto–Striatal recruitment during reward processing to persistent bingeing following treatment for binge‐eating disorder. International Journal Of Eating Disorders 2013, 47: 376-384. PMID: 24729034, PMCID: PMC3986812, DOI: 10.1002/eat.22204.Peer-Reviewed Original ResearchConceptsBinge-eating disorderFunctional magnetic resonance imagingReward processingMonetary incentive delay taskInferior frontal gyrusIncentive delay taskBinge-eating statusMedial prefrontal cortexBrain reward circuitryNeural correlatesDelay taskSpecific brain regionsFrontal gyrusNeurobiological underpinningsOutcome phasePrefrontal cortexReward circuitryVentral striatumAnticipatory phaseBrain regionsTreatment outcomesDiminished recruitmentProcessingMagnetic resonance imagingIndividualsRobust Changes in Reward Circuitry During Reward Loss in Current and Former Cocaine Users During Performance of a Monetary Incentive Delay Task
Patel KT, Stevens MC, Meda SA, Muska C, Thomas AD, Potenza MN, Pearlson GD. Robust Changes in Reward Circuitry During Reward Loss in Current and Former Cocaine Users During Performance of a Monetary Incentive Delay Task. Biological Psychiatry 2013, 74: 529-537. PMID: 23778289, PMCID: PMC3775945, DOI: 10.1016/j.biopsych.2013.04.029.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskVentral tegmental areaHealthy subjectsFormer cocaine usersLoss anticipationIncentive delay taskCocaine usersTegmental areaLoss outcomesCurrent cocaine usersDrug useAbnormal brain activation patternsCocaine addictionCurrent usersActivation patternsCocaine-using groupDelay taskLong-term cocaine abstinenceFunctional magnetic resonanceSubstance-induced alterationsBrain activation patternsCircuit abnormalitiesAnterior cingulate activationControl subjectsRisk factors
2012
Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Potenza MN. Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling. Biological Psychiatry 2012, 71: 749-757. PMID: 22336565, PMCID: PMC3460522, DOI: 10.1016/j.biopsych.2012.01.006.Peer-Reviewed Original ResearchConceptsAlcohol dependencePathological gamblingVentral striatumMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studyBrain activation changesMonetary incentive delay taskReward processingLoss processingPresent functional magnetic resonance imaging (fMRI) studyControl comparison groupIncentive delay taskVentral striatal activationPG groupMonetary rewardsVentromedial prefrontal cortexSimilar associationImaging studiesFrontostriatal activityLoss anticipationConsistent alterationsActivation changesPrefrontal cortexLevels of impulsivity
2011
An Initial Study of Neural Responses to Monetary Incentives as Related to Treatment Outcome in Cocaine Dependence
Jia Z, Worhunsky PD, Carroll KM, Rounsaville BJ, Stevens MC, Pearlson GD, Potenza MN. An Initial Study of Neural Responses to Monetary Incentives as Related to Treatment Outcome in Cocaine Dependence. Biological Psychiatry 2011, 70: 553-560. PMID: 21704307, PMCID: PMC3162064, DOI: 10.1016/j.biopsych.2011.05.008.Peer-Reviewed Original ResearchConceptsRight ventral striatumVentral striatumCocaine dependenceRight insulaMonetary incentive delay taskRight caudateReward-based decisionIncentive delay taskTreatment retentionFunctional magnetic resonanceCD participantsMedial frontal gyrusRight thalamusUrine toxicologyTreatment outcomesReward anticipationReward processingDelay taskTask performanceFrontal gyrusGreater activationNeural responsesRewarding outcomesRight subcallosal gyrusMonetary rewards
2010
Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors
Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, Stevens MC, O'Malley S, Book GA, Reynolds B, Pearlson GD. Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors. Biological Psychiatry 2010, 69: 675-683. PMID: 21126735, PMCID: PMC3677031, DOI: 10.1016/j.biopsych.2010.09.049.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskIncentive delay taskNAcc activationReward anticipationDelay taskFamily history-positive individualsAbnormal reward processingRegional brain activationNucleus accumbens activationFunctional magnetic resonanceReward system activitySubstance-abusing individualsReward prospectReward sensitivityNeural correlatesImpulsivity constructsSubstance abuse historyImpulsivity factorsReward processingBehavioral impulsivityAtypical activationBrain activationOutcome phaseBiological predispositionTask phases