2013
Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study
Narayanan B, O’Neil K, Berwise C, Stevens MC, Calhoun VD, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS, Pearlson GD. Resting State Electroencephalogram Oscillatory Abnormalities in Schizophrenia and Psychotic Bipolar Patients and Their Relatives from the Bipolar and Schizophrenia Network on Intermediate Phenotypes Study. Biological Psychiatry 2013, 76: 456-465. PMID: 24439302, PMCID: PMC5045030, DOI: 10.1016/j.biopsych.2013.12.008.Peer-Reviewed Original ResearchConceptsFirst-degree relativesSlow beta activityFast alpha activitySZ probandsAlpha activityHealthy control subjectsBeta activityRelative risk estimatesFrontal delta activityEEG spectral activityModerate relative riskPsychotic bipolar patientsLow-frequency activityPsychotic bipolar probandsGroup independent component analysisControl subjectsRelative riskPost-hoc pair-wise comparisonsBipolar patientsGenetic predispositionIntermediate Phenotypes (B-SNIP) studyOscillatory abnormalitiesAnalysis of covarianceUnique endophenotypesBipolar disorderDiffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives
Skudlarski P, Schretlen DJ, Thaker GK, Stevens MC, Keshavan MS, Sweeney JA, Tamminga CA, Clementz BA, O’Neil K, Pearlson GD. Diffusion Tensor Imaging White Matter Endophenotypes in Patients With Schizophrenia or Psychotic Bipolar Disorder and Their Relatives. American Journal Of Psychiatry 2013, 170: 886-898. PMID: 23771210, DOI: 10.1176/appi.ajp.2013.12111448.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnisotropyBipolar DisorderBrainDiffusion Tensor ImagingDominance, CerebralEndophenotypesGenetic Predisposition to DiseaseHumansImage Interpretation, Computer-AssistedLeukoencephalopathiesNerve NetPhenotypePsychiatric Status Rating ScalesReference ValuesSchizophreniaSchizophrenic PsychologyStatistics as TopicConceptsPsychotic bipolar disorderBipolar disorderWhite matter integrityFractional anisotropyComparison subjectsFractional anisotropy decreasesFirst-degree relativesHealthy comparison subjectsLower white matter integrityDiffusion tensorMultiple white matter regionsLower fractional anisotropyWhite matter regionsBipolar-Schizophrenia NetworkHealthy subjectsBipolar relativesProband groupsYoung subjectsBrain regionsDisease specificityFractional anisotropy measuresUnaffected relativesMatter regionsBrain connectivitySchizophreniaIs Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study
Khadka S, Meda SA, Stevens MC, Glahn DC, Calhoun VD, Sweeney JA, Tamminga CA, Keshavan MS, O’Neil K, Schretlen D, Pearlson GD. Is Aberrant Functional Connectivity A Psychosis Endophenotype? A Resting State Functional Magnetic Resonance Imaging Study. Biological Psychiatry 2013, 74: 458-466. PMID: 23746539, PMCID: PMC3752322, DOI: 10.1016/j.biopsych.2013.04.024.Peer-Reviewed Original ResearchConceptsPsychotic bipolar probandsNegative Syndrome Scale (PANSS) negative scoresState functional magnetic resonance imaging studyFunctional connectivityState functional magnetic resonanceBipolar disorder shareBrain connectivity abnormalitiesPosterior default mode networkSchizophrenia probandsMagnetic resonance imaging studyRespective first-degree relativesAberrant functional connectivityBipolar probandsFirst-degree relativesGroup differencesPsychosis endophenotypesNegative Syndrome ScaleResonance imaging studyFunctional magnetic resonance imaging studyDefault mode networkFunctional magnetic resonanceFunctional connectivity measures
2012
Differences in Resting-State Functional Magnetic Resonance Imaging Functional Network Connectivity Between Schizophrenia and Psychotic Bipolar Probands and Their Unaffected First-Degree Relatives
Meda SA, Gill A, Stevens MC, Lorenzoni RP, Glahn DC, Calhoun VD, Sweeney JA, Tamminga CA, Keshavan MS, Thaker G, Pearlson GD. Differences in Resting-State Functional Magnetic Resonance Imaging Functional Network Connectivity Between Schizophrenia and Psychotic Bipolar Probands and Their Unaffected First-Degree Relatives. Biological Psychiatry 2012, 71: 881-889. PMID: 22401986, PMCID: PMC3968680, DOI: 10.1016/j.biopsych.2012.01.025.Peer-Reviewed Original ResearchConceptsUnaffected first-degree relativesFirst-degree relativesPsychotic bipolar probandsBipolar probandsNegative Syndrome Scale (PANSS) scoresBipolar disorder shareFunctional brain dysconnectivityIndividual resting-state networksFunctional network connectivity analysisPANSS negative scoresResting-state networksFunctional network connectivityFunctional magnetic resonanceControl subjectsBrain dysconnectivityDisorder sharesHealthy subjectsBipolar relativesParalimbic circuitsScale scoreConnectivity differencesClinical relationshipSchizophreniaAbnormal pairsProbands