2016
Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Carroll KM, Potenza MN. Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery. Neuropsychopharmacology 2016, 41: 2112-2121. PMID: 26792441, PMCID: PMC4908642, DOI: 10.1038/npp.2016.11.Peer-Reviewed Original ResearchConceptsLeft inferior frontal gyrus activityCD participantsNegative urine screensReward/loss processingHealthy control participantsReward processingMeaningful outcome indicatorsDopamine-innervated regionsFunctional magnetic resonanceInferior frontal gyrus activityCD outpatientsTest-retest resultsPrefrontal cortex activityVentromedial prefrontal cortex activityUrine screensNeurofunctional alterationsVentral striatal activityCD groupNeurofunctional changesLong-term recoveryDrug useNeurobiological changesCocaine abstinenceCocaine dependenceStriatal activity
2013
Robust Changes in Reward Circuitry During Reward Loss in Current and Former Cocaine Users During Performance of a Monetary Incentive Delay Task
Patel KT, Stevens MC, Meda SA, Muska C, Thomas AD, Potenza MN, Pearlson GD. Robust Changes in Reward Circuitry During Reward Loss in Current and Former Cocaine Users During Performance of a Monetary Incentive Delay Task. Biological Psychiatry 2013, 74: 529-537. PMID: 23778289, PMCID: PMC3775945, DOI: 10.1016/j.biopsych.2013.04.029.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskVentral tegmental areaHealthy subjectsFormer cocaine usersLoss anticipationIncentive delay taskCocaine usersTegmental areaLoss outcomesCurrent cocaine usersDrug useAbnormal brain activation patternsCocaine addictionCurrent usersActivation patternsCocaine-using groupDelay taskLong-term cocaine abstinenceFunctional magnetic resonanceSubstance-induced alterationsBrain activation patternsCircuit abnormalitiesAnterior cingulate activationControl subjectsRisk factors