Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling
Balodis IM, Kober H, Worhunsky PD, Stevens MC, Pearlson GD, Potenza MN. Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling. Biological Psychiatry 2012, 71: 749-757. PMID: 22336565, PMCID: PMC3460522, DOI: 10.1016/j.biopsych.2012.01.006.Peer-Reviewed Original ResearchConceptsAlcohol dependencePathological gamblingVentral striatumMagnetic resonance imaging studyResonance imaging studyFunctional magnetic resonance imaging studyBrain activation changesMonetary incentive delay taskReward processingLoss processingPresent functional magnetic resonance imaging (fMRI) studyControl comparison groupIncentive delay taskVentral striatal activationPG groupMonetary rewardsVentromedial prefrontal cortexSimilar associationImaging studiesFrontostriatal activityLoss anticipationConsistent alterationsActivation changesPrefrontal cortexLevels of impulsivity