1998
Myb-dependent Regulation of Thrombospondin 2 Expression ROLE OF mRNA STABILITY*
Bein K, Ware J, Simons M. Myb-dependent Regulation of Thrombospondin 2 Expression ROLE OF mRNA STABILITY*. Journal Of Biological Chemistry 1998, 273: 21423-21429. PMID: 9694906, DOI: 10.1074/jbc.273.33.21423.Peer-Reviewed Original ResearchConceptsNIH 3T3 cellsC-MybWild-type NIH 3T3 cellsTranscription factor c-MybEndogenous target genesPost-transcriptional mechanismsPromoter-reporter assaysMRNA stability studiesDifferential display analysisSimilar transcriptional levelsTSP-2 expressionV-SrcHomology searchCDNA endsGene productsTarget genesTranscriptional levelMRNA stabilityV-mycCell cycleTSP-1C-JunHematopoietic cellsDNA probesHomologous productsRegulation of Syndecan-4 Phosphorylation in Vivo *
Horowitz A, Simons M. Regulation of Syndecan-4 Phosphorylation in Vivo *. Journal Of Biological Chemistry 1998, 273: 10914-10918. PMID: 9556568, DOI: 10.1074/jbc.273.18.10914.Peer-Reviewed Original ResearchConceptsCytoplasmic tailNovel PKC isozymesSyndecan-4Basic fibroblast growth factorProtein serine/threonine phosphatase type 1Serine/threonine phosphatasePKC isozymesSingle serine residuePhosphatase type 1Phosphatase inhibitor calyculinProtein kinase CNIH 3T3 fibroblastsThreonine phosphataseVivo phosphorylationEffects of bFGFSerine residuesTransmembrane proteoglycansConventional PKCFibroblast growth factorKinase CPhosphorylationPKC inhibitorPotential involvementGrowth factorIsozymes
1997
c‐Myb function in fibroblasts
Bein K, Husain M, Ware J, Mucenski M, Rosenberg R, Simons M. c‐Myb function in fibroblasts. Journal Of Cellular Physiology 1997, 173: 319-326. PMID: 9369944, DOI: 10.1002/(sici)1097-4652(199712)173:3<319::aid-jcp3>3.0.co;2-q.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsCalciumCell CycleCells, CulturedCytoplasmDNA-Binding ProteinsDrosophilaEmbryo, MammalianEmbryo, NonmammalianFibroblastsHeterozygoteHomeodomain ProteinsMiceMice, KnockoutProto-Oncogene ProteinsProto-Oncogene Proteins c-mybRecombinant Fusion ProteinsTrans-ActivatorsTranscription FactorsTranscription, GeneticTransfectionConceptsC-Myb proteinDominant-negative constructMyb DNA binding domainC-MybMYB family membersDNA binding domainsNegative constructsCell cycle regulationSignificant sequence homologyC-myb geneMouse embryonic fibroblastsC-Myb functionCell cycle progressionCell type expressionProtooncogene c-mybNIH 3T3 fibroblastsCell cycle arrestG1 cell cycle arrestNuclear transcription factorA-mybCycle regulationIntracellular calcium levelsB-MybTranscription factorsCDNA sequence