2000
PR39, a peptide regulator of angiogenesis
Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg R, Hampton T, Li J, Sellke F, Carmeliet P, Simons M. PR39, a peptide regulator of angiogenesis. Nature Medicine 2000, 6: 49-55. PMID: 10613823, DOI: 10.1038/71527.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimicrobial Cationic PeptidesAortaCapillariesCattleCell HypoxiaCells, CulturedCoronary VesselsCysteine EndopeptidasesDNA-Binding ProteinsEndothelium, VascularHeartHumansHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitIn Vitro TechniquesMacrophagesMiceMice, Inbred C57BLMice, TransgenicMultienzyme ComplexesMyocardial InfarctionMyocardial IschemiaNeovascularization, PhysiologicNuclear ProteinsPeptidesProteasome Endopeptidase ComplexRecombinant ProteinsSwineTranscription FactorsUbiquitinsUmbilical VeinsVon Willebrand FactorConceptsHypoxia-inducible factor-1α (HIF-1α) degradationMacrophage-derived peptideHypoxia-inducible factor-1α (HIF-1α) proteinCoronary flow studiesInflammation-induced angiogenesisInduction of angiogenesisMyocardial vasculatureTissue injuryPotent inductorFunctional blood vesselsBlood vesselsVascular structuresAngiogenesisSelective inhibitionPR39
1999
Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression ROLE OF TNF-α*
Zhang Y, Pasparakis M, Kollias G, Simons M. Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression ROLE OF TNF-α*. Journal Of Biological Chemistry 1999, 274: 14786-14790. PMID: 10329676, DOI: 10.1074/jbc.274.21.14786.Peer-Reviewed Original ResearchConceptsSyndecan-4 expressionECV cellsProtein kinase C alphaCardiac myocytesGene familySyndecan-4 mRNATNF-alphaPosttranscriptional mechanismsGene expressionPrimary cardiac myocytesUnique memberC alphaHuman endothelial cellsSyndecan-4Western analysisMouse cardiac myocytesSyndecan-4 levelsNormal myoblastsDependent mannerNF-kappaBExpressionH9c2 cellsHypoxic conditionsTumor necrosisEndothelial cells